n0乳癌再発因子としての腫瘍周囲リンパ球浸潤の意義

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  • THE SIGNIFICANCE OF TUMOR INFILTRATING LYMPHOCYTES AS THE PROGNOSTIC FACTOR IN NODE-NEGATIVE BREAST CANCER

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A clinicopathological study on prognosis has been carried out in 233 patients with breast cancer with more than twenty inspected nodes and without lymph node metastasis. Multivariate analysis of clinicopathological findings in node-negative breast cancers showed that the best combination of clinical features predicting prognosis were age, menstruation status, tumor location and tumor diameter, and from 11 pathological features, three factors (histological type, histological grade and the grade of tumor infiltrating lymphocytes) were selected under condition of p<0.05. When the three factors (solid-tubular carcinoma, histological grade III and negative tumor infiltrating lymphocytes) were provided as poor prognostic factors, node-negative breast cancers were successfully classified from the number of poor prognostic factors: namely, the recurrence rates of subgroups with the number of 3, 2, 1 and 0 were 28%, 16%, 7% and 0% respectively. We conclude that the grade of tumor infiltrating lymphocytes is especially significant as the prognostic factor in node-negative breast cancers and we must perform postoperative adjuvant therapy to the patients with node-negative breast cancer with more than two poor prognostic pathological factors.

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