TWO CASES OF BREAST CANCER WITH LIVER METASTASIS EFFECTIVELY TREATED WITH COMBINATION CHEMOENDOCRINE THERAPY MAINLY USING MITOMYCIN (MMC)

DOI Web Site 1 Citations 11 References

Bibliographic Information

Other Title
  • MMCを主体とした化学内分泌療法にて著効の得られた乳癌肝転移の2例

Search this article

Abstract

We experienced two cases of breast cancer with synchronous or metachironous liver metastasis successfully treated with chemoendocrine therapy mainly using mitomycin (MMC). Case 1: A 41-year-old woman with right breast cancer of T2aN1bM1 (liver) underwent a modified radical mastectomy. There after the patient was treated by combination chemoendocrine therapy with ADM, CPA, and 5-FU during hospital stay, followed by the therapy with 5'-DFUR at a dose of 1, 200 mg/day, tamoxifen at 20 mg/day p.o., and MMC at 10 mg/month (totally 100 mg) i. v. after discharge. The size of the liver lesions reduced effectively and serum CA15-3 level was normalized (from 124 to 9 U/ml) within a year. Case 2: A 55-year-old woman underwent a standard radical mastectomy for a left breast cancer of T1aNoMo eight years before. She also underwent lymph node on the left side of the neck and radiation therapy against lymph node metastasis 66 months after the mastectomy. The liver metastasis was found by the elevation of serum CEA and CA15-3 levels. She was treated by the similar combination therapy with UFT at a dose of 400 mg/day p.o. Medroxyprogesterone acetate at 600 mg/day p.o. and MMC at 10 mg/month i.v. (totally 100 mg). The low density areas of the liver almost disappeared and serum CEA and CA15-3 levels decreased to 2.3 ng/ml and 8 U/ml, respectively. Both estrogen receptor and progesteron eceptor levels were positive in these two cases.

Journal

Citations (1)*help

See more

References(11)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top