多核巨細胞を伴った乳腺紡錘細胞癌の1例

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  • A CASE OF SPINDLE CELL CARCINOMA OF THE BREAST WITH MULTINUCLEATED GIANT CELLS

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Spindle cell carcinomas of the breast are relatively rare and represent 0.12-0.15% of all breast cancers. This paper describes a case of spindle cell carcinoma of the breast with multinucleated giant cells. A 58-year-old woman had noticed a nodule in the right breast 17 years before. Recently, the nodule showed a very rapid growth and she was referred to the hospital. A malignant breast tumor, probably non-epithelial tumor, was diagnosed by aspiration biopsy cytology. Standard radical mastectomy was carried out. Histopathologically, the tumor consisted of parts of sarcomatoid and invasive intraductal carcinoma, and multinucleated giant cells were scattered on the former part. A diagnosis of spindle cell carcinoma was made. She died of pulmonary embolism due to fracture 8 months following the mastectomy. Immunohistochemically, Keratin, EMA and Vimentin were positive in both parts of sarcomatoid and intraductal carcinoma. ER was positive in only intraductal carcinoma part. It was, therefore, supposed that some intraductal carcinoma cells in this tumor were transformed into sarcomatoid cells. Multinucleated giant cell was suggested to derive from phagocyte, because CD68 recognizing macrophage was positive in multinucleated giant cells.

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