胆管癌におけるepidermal growth factor receptorおよびc-erbB-2蛋白発現の臨床的意義

• 佐々木 亮孝

  岩手医科大学第1外科

• 船渡 治

  岩手医科大学第1外科

• 村上 雅彦

  岩手医科大学第1外科

• 早川 善郎

  岩手医科大学第1外科

• 島田 裕

  岩手医科大学第1外科

• 川村 英伸

  岩手医科大学第1外科

• 須藤 隆之

  岩手医科大学第1外科

• 斎藤 和好

  岩手医科大学第1外科

書誌事項

タイトル別名

• CLINICAL SIGNIFICANCE OF THE EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR AND C-erbB-2 PROTEIN IN THE BILE DUCT CANCER

抄録

The expression of epidermal growth factor (EGFR) and c-erbB-2 protein were examined immunohistochemically in a total of 45 cases of bile duct cancer, and corelations between these expressions and clinicopathological variables were analyzed. The expression of EGFR and c-erbB-2 protein were observed in 17 of 45 cases (37.8%) respectively. There were no significant correlation between these expression and clinicopathological factors including the cell differentiation, tumor diameter, depth of invasion, lymph node involvement, stage, and vascular invasion. Five years survival rate in EGFR positive cases was 31.7% versus 61.7% in EGFR negative cases with a significant difference. Prognosis of patients with EGFR positive cancer was worse than those with EGFR negative cancer (p=0.04). Prognosis of patients with lymph node metastasis was also worse than those without lymph node metastasis (p=0.02).<br> These results suggest that expression of EGFR may serve as a useful biological marker as well as nodal involvement in the bile duct cancer.

収録刊行物

• 日本臨床外科医学会雑誌

  日本臨床外科医学会雑誌 58 (7), 1468-1473, 1997

  日本臨床外科学会

キーワード

• bile duct cancer
• epidermal growth factor receptor
• c-erbB-2 protein
• immunohistochemistry

詳細情報

• CRID: 1390282680291361024
• NII論文ID: 130003600529
• NII論文ID: 10008528440
• NII書誌ID: AN00198696
• DOI: 10.3919/ringe1963.58.1468
• ISSN: 21892075
• ISSN: 03869776
• Web Site: http://www.jstage.jst.go.jp/article/ringe1963/58/7/58_7_1468/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998015224
• データソース種別:
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  • Crossref
  • CiNii Articles
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