CLINICAL SIGNIFICANCE OF THE EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR AND C-erbB-2 PROTEIN IN THE BILE DUCT CANCER

• SASAKI Ryoko

  Department of Surgery I, Iwate Medical University School of Medicine

• FUNATO Osamu

  Department of Surgery I, Iwate Medical University School of Medicine

• MURAKAMI Masahiko

  Department of Surgery I, Iwate Medical University School of Medicine

• HAYAKAWA Yoshiro

  Department of Surgery I, Iwate Medical University School of Medicine

• SHIMADA Yutaka

  Department of Surgery I, Iwate Medical University School of Medicine

• KAWAMURA Hidenobu

  Department of Surgery I, Iwate Medical University School of Medicine

• SUTO Takayuki

  Department of Surgery I, Iwate Medical University School of Medicine

• SAITO Kazuyoshi

  Department of Surgery I, Iwate Medical University School of Medicine

Bibliographic Information

Other Title

• 胆管癌におけるepidermal growth factor receptorおよびc-erbB-2蛋白発現の臨床的意義

Abstract

The expression of epidermal growth factor (EGFR) and c-erbB-2 protein were examined immunohistochemically in a total of 45 cases of bile duct cancer, and corelations between these expressions and clinicopathological variables were analyzed. The expression of EGFR and c-erbB-2 protein were observed in 17 of 45 cases (37.8%) respectively. There were no significant correlation between these expression and clinicopathological factors including the cell differentiation, tumor diameter, depth of invasion, lymph node involvement, stage, and vascular invasion. Five years survival rate in EGFR positive cases was 31.7% versus 61.7% in EGFR negative cases with a significant difference. Prognosis of patients with EGFR positive cancer was worse than those with EGFR negative cancer (p=0.04). Prognosis of patients with lymph node metastasis was also worse than those without lymph node metastasis (p=0.02).<br> These results suggest that expression of EGFR may serve as a useful biological marker as well as nodal involvement in the bile duct cancer.

Journal

• The journal of the Japanese Practical Surgeon Society

  The journal of the Japanese Practical Surgeon Society 58 (7), 1468-1473, 1997

  Japan Surgical Association

Keywords

• bile duct cancer
• epidermal growth factor receptor
• c-erbB-2 protein
• immunohistochemistry

Details

• CRID: 1390282680291361024
• NII Article ID: 130003600529
• NII Article ID: 10008528440
• NII Book ID: AN00198696
• DOI: 10.3919/ringe1963.58.1468
• ISSN: 21892075
• ISSN: 03869776
• Web Site: http://www.jstage.jst.go.jp/article/ringe1963/58/7/58_7_1468/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998015224
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed