A CLINICAL STUDY ON THE NECESSITY OF CHEMICAL CLEANING IN PATIENTS WITH COLORECTAL CANCER

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  • 大腸癌症例におけるchemical cleaningの必要性の検討

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Abstract

Seventy-eight patients who were operated on for colorectal cancer from November 1994 to December 1995 were divided into two groups with random sampling; 33 patients were orally administered antibiotics (kanamycin+clindamycin) for chemical cleaning (Chemical Cleaning Group) and 45 patients were not administered antibiotics (No Chemical Cleaning Group) preoperatively. The frequency of leakage and wound infection were compared between the Chemical Cleaning Group and No Chemical Cleaning Group. There was no significant difference in the frequency of leakage and wound infection between two groups. Furthermore, these patients were divided into another two groups by the presence of stenosis (more than one third of the intestinal lumen was stenosed) based on barium enema study, and a similar study was conducted in the stenotic and non-stenotic groups. Entirly no significant difference in the frequency of leakage and wound infection was noted in non-stenotic cases (x2=0.000, p=1.000). It was thought that non-stenotic cases demanded no chemical cleaning. But, there was a tendency in stenotic cases that the leakage and wound infection were found more frequently in the No Chemical Cleaning Group than in the Chemical Cleaning Group. More studies in stenotic cases are needed.<br> This study suggested that the chemical cleaning would not be necessary for patients with colorectal cancer who had no stenosis.

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