乳腺腫瘍中心部温度測定の臨床病理学的意義に関する検討 [in Japanese] THE CLINICOPATHOLOGICAL SIGNIFICANCE OF MEASUREMENT OF THE TEMPERATURE IN THE CENTER OF BREASE TUMOR [in Japanese]
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乳腺の良・悪性腫瘍の内部温度を直接測定し,腫瘍温の臨床的意義を検討した.とくに,悪性腫瘍においては内部温度と臨床病理学的進行度および腫瘍新生血管などの予後因子との関係を検討した.対象は乳腺腫瘍57例(乳癌35例,線維腺腫22例)で,穿刺吸引細胞診施行時超音波ガイド下に先端部に熱電対を封入した21ゲージ針を腫瘍内に刺入して腫瘍内温度を測定,同時に腫瘍直上の皮膚温も測定した.腫瘍新生血管は第8因子関連抗原を用いた免疫染色法により求めた.<br> 結果: 1)腫瘍中心温(平均)は悪性例が有意に高かった(p<0.01). 2)腫瘍径が大きいほど高温傾向がみられた. 3)腫瘍中心温は組織型による差, n・ly・vの有無による差はなかったが病期IIはIより高温の傾向がみられた. 4)腫瘍新生血管密度の高い症例は腫瘍中心温と皮膚温の差が大であった.結論:腫瘍内部温は良性例より悪性が有意に高く,その温度は腫瘍新生血管との密接な関係が示唆された.
The temperatures of central portion of both benign and malignant breast tumors were measured directly to study the clinicopathological significance of the tumor temperature. Particularly for malignant tumors, the relationships between the internal temperature and clinicopathological stage as well as prognostic factors such as vacularization were investigated. Subjects were 57 patients with breast tumor including 35 with breast cancer and 22 with fibroadenoma. During a needle aspiration biopsy cytology, a 21-gauge needle with a thermocouple sealed in the tip was inserted in the tumor under ultrasonic guide to measure the internal temperature, while simultaneously measuring the skin temperature just over the tumor. Vascularization of the tumor was determined by immunostaining method using a factor VIII related antigen.<br> Results: 1) The averaged temperature in the central part of the tumor was significantly higher in malignant cases (p<0.01). 2) The temperature tended to increase as the diameter of the tumor increased. 3) There was no difference in the temperature of the tumor center by tissue types or presence of n, ly, and v, but the temperature tended to increase in stage II tumors compared to stage I tumors. 4) In cases with high density of vascularization in the tumor, a greater difference in the temperature between the center of the tumor and skin over the tumor was noted.<br> Conclusion: The internal temperature of the breast tumors was significantly higher in the malignant cases than that in benign cases, and a close correlation between the temperature and vascularization of the tumor has been suggested.
- The journal of the Japanese Practical Surgeon Society
The journal of the Japanese Practical Surgeon Society 58(12), 2760-2764, 1997-12-25
Japan Surgical Association