A clinical study on levofloxacin concentration in the skin on antibiotic prophylaxis for outpatient surgery.

• Nakatani Yoshihiro

  Second Department of Surgery, Wakayama Medical University

• Uchiyama Kazuhisa

  Second Department of Surgery, Wakayama Medical University

• Tanimura Hiroshi

  Wakayama Rosai Hoapital

Bibliographic Information

Other Title

• 抗菌薬（ｌｅｖｏｆｌｏｘａｃｉｎ）の皮膚組織内移行からみたｄａｙ　ｓｕｒｇｅｒｙにおける創感染阻止効果の検討

Abstract

The growing use of outpatient surgery has necessitated antibiotic agents having good tissue penetration after oral administration. We studied the skin penetration of levofloxacin, an oral fluoroquinolones, in surgical patients and conducted a clinical trial on antibiotic prophylaxis for wound infection. Levofloxacin concentrations in serum and skin were measured after single oral administration of 200mg in 15 surgical patients. Serum concentrations ranged from 0.05 to 3.46μg/mL and tissue concentrations ranged from 0.13 to 3.36μg/g between 2h and 3h after administration, confirming that levofloxacin is an effective antibiotic prophylactic for wound infection in outpatient surgery due to its sustained high skin concentration.

Journal

• Japanese Journal of Chemotherapy

  Japanese Journal of Chemotherapy 50 (4), 223-226, 2002

  Japanese Society of Chemotherapy

Keywords

• levofloxacin

Details

• CRID: 1390282681261492480
• NII Article ID: 130004298111
• NII Article ID: 10008541829
• NII Book ID: AN10472127
• DOI: 10.11250/chemotherapy1995.50.223
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2002213300
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed