Transparent, opaque and rough colonial variant susceptibility of Mycobacterium intracellulare to antimicrobial drugs.

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  • Sato Katsumasa
    Department of Microbiology and Immunology, Shimane Medical University
  • Tomioka Haruaki
    Department of Microbiology and Immunology, Shimane Medical University
  • Sano Chiaki
    Department of Microbiology and Immunology, Shimane Medical University
  • Shimizu Toshiaki
    Department of Microbiology and Immunology, Shimane Medical University
  • Sano Keisuke
    Department of Microbiology and Immunology, Shimane Medical University Department of Otorhinolaryngology, Shimane Medical University
  • Matsushima Toshiharu
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School

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  • Ｍｙｃｏｂａｃｔｅｒｉｕｍ　ｉｎｔｒａｃｅｌｌｕｌａｒｅの異なる集落変異株の各種抗菌薬に対する感受性について

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Abstract

Mycobacterium avium-intracellulare complex (MAC) has 3 colonial variants-SmT with smooth, transparent, irregularly shaped colonies; SmO with smooth, opaque, dome-shaped colonies; and Rg with rough, granular, irregularly shaped colonies. These colonial variants differ in virulence in experimental animals. We compared the susceptibilities of 3 colonial variants isolated from identical M. intracellulare strain to rifampicin, rifabutin, streptomycin, kanamycin, ethambutol, isoniazid, ofloxacin, ciprofloxacin and cefoxitin, using 7 M. intracellulare strains isolated from patients with MAC pulmonary infection. SmT variants were much more resistant to tested antimicrobial drugs, except for ethambutol and isoniazid, than SmO variants. Rg variant susceptibility patterns to tested drugs proved to lie between SmT and SmO variants, indicating the importance of determining the MAC strain colony form isolated from clinical specimens in determining drug susceptibility.

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