尿素呼気試験に与える粘膜防御因子増強剤の影響 : RebamipideとEcabet sodiumの比較 Effect of antiulcer agents on the urea breath test : Comparison between rebamipide and ecabet sodium

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著者

    • 水野 元夫 MIZUNO Motowo
    • 岡山大学大学院消化器・肝臓・感染症内科 Department of Medicine (Gastroenterology, Hepatology and Infectious diseases), Okayama University Graduate School of Medicine and Dentistry
    • 河合 公三 KAWAI Kozo
    • 岡山大学大学院消化器・肝臓・感染症内科 Department of Medicine (Gastroenterology, Hepatology and Infectious diseases), Okayama University Graduate School of Medicine and Dentistry
    • 高口 浩一 TAKAGUCHI Kouichi
    • 岡山大学大学院消化器・肝臓・感染症内科 Department of Medicine (Gastroenterology, Hepatology and Infectious diseases), Okayama University Graduate School of Medicine and Dentistry
    • 吉田 康博 YOSHIDA Yasuhiro
    • 岡山大学大学院消化器・肝臓・感染症内科 Department of Medicine (Gastroenterology, Hepatology and Infectious diseases), Okayama University Graduate School of Medicine and Dentistry
    • 辻 孝夫 TSUJI Takao
    • 岡山大学大学院消化器・肝臓・感染症内科 Department of Medicine (Gastroenterology, Hepatology and Infectious diseases), Okayama University Graduate School of Medicine and Dentistry

抄録

RebamipideとEcabet sodiumの<SUP>13</SUP>C-尿素呼気試験(UBT)に与える影響を検討した.無投薬では,赤外分光計により測定したUBT値は,平均4.4カ月の経過で有意な変化は認めなかった.器質的疾患を有さない<I>Helicobacterer pylori</I>(<I>H.pylori</I>)陽性患者21名に,RebamipideとEcabet sodiumの無作為割付を行い,28日間投与した,UBTは,投与前,投与14日目,28日目,投与中止14日目に施行した.RebamipideはUBT値に影響をおよぼさなかったが,Ecabet sodiumは,14日目でUBT値が有意に低下した(p=0.0113).また,Ecabet sodiumを投与した11例中1例に偽陰性を生じた.この影響は薬剤投与中止2週後には消失した.さらに,<I>H.pylori</I>陽性ボランティアに対するクロスオーバー法による検討でも,Ecabet sodiumはRebamipideと異なり,UBT値を有意に低下させた(p=0.0058).以上より,Ecabet sodiumはUBTの正確性に影響を及ぼし,偽陰性を避けるためにUBT施行前には休薬期間を要することが明らかとなった.

In this study, we assessed whether standard doses of antiulcer drugs rebamipide, and ecabet sodium influence the accuracy of the urea breath test (UBT). Without medication, values of UBT estimated with nondispersive isotope-selective infrared spectrometry did not significantly change during follow-up (average 4.4 months). Then, we randomized 21 <I>H. pylori</I>-positive patients without serious disease to receive either rebamipide or ecabet sodium for 28 days. UBT was performed at baseline, on day 14, on day 28, and 2 weeks after cessation of drugs. On day 14, the median value of UBT declined significantly (p = 0.0113) compared to baseline with ecabet sodium but not with rebamipide. This caused a false-negative result of UBT in one of 11 patients who received ecabet sodium. The decline of UBT resolved 2 weeks after drug cessation. In addition, we performed a crossover study in 11 <I>H. pylori</I>-positive volunteers with these drugs, and ecabet sodium but not rebamipide significantly reduced UBT values (p = 0.0058). These findings indicate that ecabet sodium adversely influences the accuracy of UBT and that the withdrawal of this drug before testing appears to be necessary to avoid false-negative results.

収録刊行物

  • 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology

    日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 99(1), 27-33, 2002-01-05

    The Japanese Society of Gastroenterology

参考文献:  26件中 1-26件 を表示

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各種コード

  • NII論文ID(NAID)
    10008554038
  • NII書誌ID(NCID)
    AN00192124
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    04466586
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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