中心・中側頭部に棘波を有する小児てんかんに対するクロナゼパムの効果 : とくにRolandic dischargeの経過  [in Japanese] Effect of Clonazepam for Benign Childhood Epilepsy with Centro-temporal Spikes  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

未治療の中心・中側頭部に棘波を有する小児てんかん (BCECT) 20例に対しクロナゼパム (CZP) を投与しRolandic discharge (RD) の消失と臨床発作の消失について経時的に検討した。CZP服用1週間目の脳波で13例中6例はRDは消失した。1カ月目の脳波では20例中15例 (75%) でRDは消失した。<BR>1カ月目にRDが消失した15例のうち脱落した3例を除く12例にCZPをひきつづいて投与し, RDと臨床発作の経過を検討した。10例は3カ月から2年6カ月の間にRDが再出現し, このうち7例で臨床発作も再発した。<BR>CZPに対し早期に反応し, 消失することはRDの特徴のひとつと考えられた。RD早期消失例と非消失例の間には臨床像の差はみられなかった。CZPの服用を続けるとRDおよび臨床発作に再発がみられ, BCECTの治療薬としては本剤は第一選択剤にはなり得ず, 今後服用方法の検討が必要と思われた。

We evaluated the efficacy of clonazepam (CZP) treatment for Rolandic discharge (RD) in patients suffering from benign childhood epilepsy with centro-temporal spikes (BCECT). Twenty newly diagnosed patients received CZP twice a day. The dose administered ranged form 0.35 to 1.0mg/day. Both before and one month after the institution of the medication, the EEGs of each patient were evaluated in both the awake and natural sleeping states.<BR>The RD disappeared in the EEG of 15 patients one month after beginning the medication. We also recorded the EEGs in 13 patients one week after starting the medication. In 6 of these 13 patients the RD had already disappeared by that point.<BR>In 12 of 15 patients whose RD disappeared one month after the start of medication, the efficacies of CZP for RD in EEG and for seizures were continuously investigated for from 8 months to 6 years and 8 months. RD appeared again in 10 patients and 6 of these 10 patients had a relapse of seizures.<BR>We thus propose that the immediate efficacy of CZP for RDs be accepted as a new characteristic of the EEG in BCECT. However, long term monotherapy with CZP for BCECT is not necessarily recommended because tolerance to this therapy would be expected to develop in the long run.

Journal

  • Journal of the Japan Epilepsy Society

    Journal of the Japan Epilepsy Society 13(3), 211-219, 1995-10-31

    JAPAN EPILEPSY SOCIETY

References:  23

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008555475
  • NII NACSIS-CAT ID (NCID)
    AN10043823
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09120890
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top