Interictal Noninvasive Measurements of Regional Cerebral Blood flow Using Technetium-99m Hexamethylprophylene Amine Oxime in Temporal Lobe Epilepsy

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  • Fukuchi Toshihiko
    Department of Neuropsychiatry, Aichi Medical University
  • Matsuda Hiroshi
    Department of Radiology, National Center Hospi tal for Mental, Nervous and Muscular Disorders
  • Onuma Teiichi
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders
  • Ishida Shiro
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders

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  • 発作問欠期の側頭葉てんかんにおけるtechnetium-99mhexamethylpropylene amine oxime (<SUP>99m</SUP>Tc-HMPAO) を用いたSPECTによる非侵襲的脳血流量測定

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Abstract

Interictal noninvasive measurements of regional cerebral blood flow (r CBF) using 99mTc-HMPAO SPECT were performed on 43 patients with temporal lobe epilepsy. Mean cerebral blood flow (m CBF) showed significant negative correlation with advancing age and duration of illness and mean cerebellar blood flow (m Cbl BF) showed weak negative correlation with duration of illness. Patients taking phenytoin had signigicantly lower m CBF and lower m Cb1BF than those not taking phenytoin. Patients with both visually detected temporal hypoperfusion on SPECT and hippocampal sclerosis on MRI showed quantitatively lower r CBF in the temporal region and more wide-spread hypoperfusion than patients without the both of image findings. Our results suggest that interictal noninvasive cerebral blood flow measure ments using 99mTc-HMPAO may give useful information about not only cerebral blood flow in the epileptic focus and its adjacent area but also the effects of antiepileptic drugs on brain function in temporal lobe epilepsy.

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