Effects of Antiepileptic Drugs on Epoxide Hydrolase and Glutathione S-transferase Activities
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- Tokinaga Noboru
- Department of Neuropsychiatry, Hirosaki University School of Medicine
Bibliographic Information
- Other Title
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- 抗てんかん薬のepoxide hydrolaseおよび glutathione S-transferase活性に対する作用
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Abstract
Epoxide hydrolase (EH) and glutathione S-transferase (GST) are involved in the detoxification of epoxide, which may be attributable to the mechanism of ter-atogenicity of antiepileptic drugs (AEDs).In this study, such AEDs as phenytoin (PHT), phenobarbital (PB), carbamazepine (CBZ), zonisamide (ZNS) and valproic acid (VPA) on the activities of these enzymes were investigated using rat liver microsomes.Within respective therapeutic concentrations, PHT, PB, CBZ and ZNS did not affect EH activity while VPA showed a concentration-dependent inhibitory effect on EH activity at 100μg/mlor more.Regarding the activities of GST isozymes, PHT and ZNS did not affect the activities at any concentrations studied while CBZ (10μg/ml or more) and PB (40μg/ml or more) inhibited GST 7-7 activity.VPA showed concentration-dependent inhibitory effects on activities of GST 1-1, 2-2, 4-4 ad 7-7 at 100μg/ml or more.These results may partly explain the increased incidences of malformation in offspring exposed to AED polytherapy including VPA, CBZ and PB through the accumulation of epoxide intermediates of AEDs.
Journal
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- Journal of the Japan Epilepsy Society
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Journal of the Japan Epilepsy Society 15 (3), 165-171, 1997
JAPAN EPILEPSY SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679492789376
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- NII Article ID
- 10008555783
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- NII Book ID
- AN10043823
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- ISSN
- 13475509
- 09120890
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- HANDLE
- 10129/4216
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed