側頭葉てんかんにおける周嗅領皮質 (perirhinal cortex) の役割 : キンドリングネコを用いた実験的研究  [in Japanese] The Perirhinal Cortex and the Seizure Generalization of Kindling in the Cat  [in Japanese]

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Abstract

ネコを用いて、扁桃核キンドリングにおける周嗅領皮質 (perirhinal cortex: PRC) の脳波活動を観察した。さらにPRCを一次刺激部位としたキンドリングを行い、その発展形式を観察した。扁桃核キンドリング早期よりPR℃に後発射が出現し、発作全般化に際して反対側半球ではPRCで後発射が最も優勢であった。キンドリング完成後の発作問激期放電 (IID) には4つの出現形式がみられたが、すべての出現形式でIIDが観察されたのはPRCのみであった。PRC一次キンドリングの発作症状と後発射の観察から、海馬、新皮質、扁桃核の順に発展する様式がみられ、新皮質キンドリングの発展に類似したが、完成キンドリングの安定性などは辺縁系キンドリングの性質に一致した。これらの結果より、PRCはその辺縁系と新皮質への密接な関係から、キンドリング発作全般化において、重要な役割を持つことが考えられた。

The Perirhinal Cortex and the Seizure Generalization of Kindling in the Cat Akihisa Orita It has recently been demonstrated that the perirhinal cortex (PRC) is an impor-tant site for the generalization of kindled seizures.In this study, we observed charac-teristics of afterdischarges (ADs) in the PRC during amygdala kindling as well as the characteristics of the primary PRC kindling. PRC produced apparent ADs during the early stage of amygdala kindling. ADs were most predominant in PRC in the contralateral hemisphere when the animals showed stage 3 motor seizures.Analysis of interictal discharges (IIDs) revealed that there are four patterns in the distribution of IIDs. Only PRC always showed IIDs in every IID pattern. The development of motor seizures and ADs in the primary PRC kindling demonstrated that PRC kindling-induced epileptic activity was propagated first to the hippocampus, followed by the neocortex and then the amygdala before the full-down seizures. PRC kindled seizures were stably reproducible after the completion of kindling. These results suggest that PRC appears to be important for the seizure generalization of amygdala kindling. The development of PRC kindling is similar to that of neocortical kindling, although the stability of fully-developed seizures indicated that it is more similar to seizures from the limbic sites, suggesting that PRC kindling has characteristics from both neocor-tical and limbic kindling.

Journal

  • Journal of the Japan Epilepsy Society

    Journal of the Japan Epilepsy Society 15(3), 189-199, 1997-10-31

    JAPAN EPILEPSY SOCIETY

References:  14

Codes

  • NII Article ID (NAID)
    10008555856
  • NII NACSIS-CAT ID (NCID)
    AN10043823
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    09120890
  • Data Source
    CJP  J-STAGE 
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