日本語版SEALSの多施設共同研究  [in Japanese] A Multi-Institutional Study of a Japanese Version of the Side Effects and Life Satisfaction (SEALS)  [in Japanese]

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Abstract

著者らは、抗てんかん薬治療に付随する副作用を評価するためにイギリスで開発されたSide Effects and Life Satisfaction (SEALS) を本邦に導入し、日本語版 (SEALS-J) の信頼性と妥当性を多施設共同研究によって評価した。対象症例は、通常の社会生活を営む317例の成人の通院てんかん患者である。さらに、患者群と年齢を対応させた健常者100名を抽出して対照群とした。患者群と対照群にSEALS-Jへの回答を依頼し、検査結果と多彩な臨床特徴との関連を多角的に検討した。SEALS-Jの信頼性は、患者群と対照群のCronbachのa係数と患者群の検査-再検査法による相関係数によって実証された。妥当性は、臨床特徴の差異を検出する感受性によって支持された。SEALS-Jの結果に対しては、てんかん変数 (てんかん類型、発作頻度、併用薬剤数) および心理社会学的変数 (精神症状、就労状況) が統計学的に有意の影響を及ぼしていた。てんかん研究1998; 16: 1-8

We introduced the Side Effects and Life Satisfaction (SEALS) to Japan with permission. This battery was originally developed in the United Kingdom to investigate subjective adverse events which associated with antiepileptic pharmacotherapy. We investigated the reliability and validity of a Japanese version (SEALS-J) by means of a multi-institutional study. Three hundred and seventeen patients with epilepsy (153men and164women with mean age of37years) and one hundred normal controls (50 men and50women with mean age of35years) participated in this study. They were asked to complete the SEALS-J after providing informed consent. To assess the test -retest reliability, the SEALS-J was completed at two time assessments b119 patients at four week intervals.Reliability was estimated using Cronbach's alpha and test-retest method.The former value of totals scale score of case subjects and normal controls were0.89and0.94, respectively. Correlation coefficient of that score by test -retest method was 0.85. These results indicate that the SEALS-J has good construction reliability. Validity was evaluated by comparing SEALS-J scores with patients' multidimensional clinical characteristics. The test results of the SEALS-J were influenced by epilepsy and psychosocial variables with statistical significance.

Journal

  • Journal of the Japan Epilepsy Society

    Journal of the Japan Epilepsy Society 16(1), 1-8, 1998-02-28

    JAPAN EPILEPSY SOCIETY

References:  13

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008555892
  • NII NACSIS-CAT ID (NCID)
    AN10043823
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09120890
  • Data Source
    CJP  CJPref  J-STAGE 
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