実形状頭部3層モデルを用いた双極子追跡法によるてんかん焦点の推定  器質性疾患周囲における等価電流双極子分布の検討

書誌事項

タイトル別名
  • Localization of the Epileptic Focus by Dipole Tracing Method of an Inhomogeneous Realistic Head Model. 'Distribution of Equivalent Current Dipoles Around the Organic Lesion'.
  • Distribution of Equivalent Current Dipoles Around the Organic Lesion
  • 器質性疾患周囲における等価電流双極子分布の検討

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Purpose: To evaluate the usefulness of dipole tracing method with realistic head model, we examined the locations of equivalent current dipole (ECD) around the organic lesion cases.<BR>Subjects and Method: Five organic lesion cases were evaluated in this study. For the accuracy of data, we used dipole tracing method of realistic head model with inhomogeneous electrical conductivity, superimposed ECD over the realistic head model (ECD, dipolarity>0.98), and calculated the ECD concentration around the lesion.<BR>Results: Most of ECDs were located around the lesion in all cases. The ECD concentration ratio was ranged from 70 to 90% within 20 mm around the lesion.<BR>Neuroimaging examination showed clear margin of the organic lesion, a correlated to the scalp EEG showed spikes from the electrodes located near the lesion. Based on these preoperative evaluations, the organic lesion was totally resected. Four patients have been seizure free, and one patient has had seldom seizure after the operation (mean follow-up term 25 month).<BR>Conclusions: Dipole tracing method of a realistic head model appeared to be useful to estimate the epileptogenic zone. Seventy percent of ECDs within an area 20 mm apart from the lesion are necessary, provided neuroimaging and scalp EEG, concordant results are found, there0fore, epilepsy could be controlled by a simple lesionectomy.

収録刊行物

  • てんかん研究

    てんかん研究 18 (2), 114-123, 2000

    一般社団法人 日本てんかん学会

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