良性小児てんかんにおけるローランド発射の脳磁図による研究 : 症候性部分てんかんの棘波と比較した電流モーメントの特徴  [in Japanese] A Magnetoencephalographic Study on Rolandic Discharges in Benign Childhood Epilepsy : Characteristics of the Current Moment Compared with that of the Spike Discharges in Symptomatic Partial Epilepsy  [in Japanese]

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Author(s)

    • SATOH Susumu
    • EEG Station, National Institute of Neurological Disorders and Stroke, National Institutes of Health

Abstract

中心・側頭部に棘波をもつ良性小児てんかん (BECT) 5例の脳磁図を記録し、ローランド発射 (RD) の等価電流双極子 (ECD) 解析を行った。ECDの電流モーメント (Q) の分布について、RDと年齢分布の一致した症候性部分てんかん (SPE) 9例の棘波との結果を比較検討した。結果、BECT、SPE両群ともにQの分布は正規分布ではなかったが、対数に変換すると正規分布を示した。対数正規分布から導いたQの平均値は、BECT群では272nAm (mean±SD144-514nAm) 、SPE群では、177nAm (mean±SD109-286nAm) であった。RDのQはSPEの棘波のQに比べ、有意に大きく、より幅広く分布した。さらに、RDは、発作の消失とともに比較的短期間に小棘波に変化し、そのQも著明に減少した。Qの検討から、RDは、SPEの棘波に比べ、より多くの、より可変性のある数の神経細胞集団が同期的に興奮することにより生じていると考えられた。

We recorded simultaneously magnetoencephalogram and electroencephalogram and analyzed equivalent current dipoles (ECDs) of rolandic discharges (RDs) in 5 patients with benign childhood epilepsy with centrotemporal spikes (BECT). In addition to ECDs localization, we studied the current moment (Q) of ECDs, which reflects the size of synchronously active neuronal population. The distribution of the Q of 441 RDs was examined and compared with that of 512 spike discharges of nine age-matched patients with symptomatic partial epilepsy (SPE). Although the raw data of the Q was not normally distributed, the distribution after the logarithmic conversion revealed a normal distribution in both BECT and SPE. Consequently, the mean non-logarithmic Q value of RDs was 272 nAm (mean±SD 144-514 nAm) and that of spike discharges was 177 nAm (mean±SD 109-286 nAm). The Q of RDs was significantly larger and more widely distributed than that of spike discharges in SPE. Moreover, the Q of RDs markedly decreased in a relatively short period of time with cessation of the seizure. In conclusion, the RDs would be likely to originate from highly synchronous activity of more numerous and more changeable neuronal populations compared with the spike discharges in SPE.

Journal

  • Journal of the Japan Epilepsy Society

    Journal of the Japan Epilepsy Society 18(2), 124-132, 2000-06-30

    JAPAN EPILEPSY SOCIETY

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008556260
  • NII NACSIS-CAT ID (NCID)
    AN10043823
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09120890
  • Data Source
    CJP  CJPref  J-STAGE 
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