双極子追跡法を用いた側頭葉てんかんの脳内電源推定 : 硬膜下電極記録との比較検討  [in Japanese] Estimation Generator Sources in Temporal Lobe Epilepsy with Dipole Tracing : Comparison of Subdural Electrode Recording  [in Japanese]

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Author(s)

Abstract

頭皮·頭蓋·脳実質のそれぞれの導電率を1:1/80:1とした3層頭部モデルを用いた双極子追跡法により側頭葉てんかん(TLE)患者の棘波から等価電流双極子(ECD)を推定し、硬膜下電極記録により同定したてんかん発作焦点部位と比較検討した。対象は発作抑制が困難な難治TLEの5例。年齢は17歳から67歳、平均43歳。男性3例、女性2例。3例は内側TLEで2例は外側TLEであった。ECDの集中する部位と硬膜下電極記録による発作焦点の中心部位との距離は、8∼18mm、平均14mmであった。推定された等価電流双極子の位置は、内側側頭葉てんかんでは内側部よりむしろ側頭葉底部に認められ、海馬からの興奮が波及する部位を示していた。外側側頭葉てんかんでは、より正確に外側皮質の興奮部位を示した。

We estimated equivalent current dipoles (ECDs) using dipole tracing method with realistic head model in patients with temporal lobe epilepsy and compared them to the epileptic focus identified by subdural electrode recording. The mean patient age was 43 years (range 17-67 years). Three patients were men and two patients were women. Three patients had mesial temporal lobe epilepsy and two patients had lateral temporal lobe epilepsy. The mean distance between the center of ECDs and the center of epileptic focus identified by subdural electrode recording was 14 mm (range 8-18 mm). In patients with mesial temporal lobe epilepsy, we estimated ECDs in temporal base rather than mesial temporal lobe. We though epileptic activiry spread from hippocamps to temporal basal cortex where we estimated ECDs. In patients with lateral temporal lobe epilepsy, ECDs showed activated lateral cortex precisely.

Journal

  • Journal of the Japan Epilepsy Society

    Journal of the Japan Epilepsy Society 19(1), 3-10, 2001-02-28

    JAPAN EPILEPSY SOCIETY

References:  26

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008556325
  • NII NACSIS-CAT ID (NCID)
    AN10043823
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09120890
  • Data Source
    CJP  CJPref  J-STAGE 
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