Spontaneous Pituitary Adenomas of the Pars Intermedia in 5 Aged Horses: Histopathological, Immunohistochemical and Ultrastructural Studies.
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- YOSHIKAWA Hiroyasu
- Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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- OISHI Hideo
- Exercise Physiology of Racehorse Lab.
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- SUMI Akiko
- Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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- UEKI Hideaki
- Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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- OYAMADA Toshifumi
- Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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- YOSHIKAWA Takasi
- Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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Abstract
Adenomas that developed in the pars intermedia of 1 Anglo-Arab and 4 thoroughbred horses aged 19 to 29 years were examined by light microscopy, electron microscopy and immunohistochemistry. The tumors had a nodular growth pattern separated by connective tissue and often invaded the pars nervosa irregularly. The tumor cells were spindle cells with abundant basophilic cytoplasm and proliferated in a palisade arrangement in line with the blood capillaries. Histochemically, the tumor cells were stained light red with periodic acid-Schiff-Orange G stain and purple with aldehyde thyonine, thereby showing a chromatic similarity to basophilic cells of the normal pars intermedia and the pars distalis. Immunohistochemically, the tumor cells were positive for adrenocorticotropic hormone (ACTH) and also weakly positive for α-melanocyte stimulating hormone (α-MSH), β-lipotropin (β-LPH) and β-endorphin (β-END). Since these hormones are synthesized from the prohormone, proopiomelanocortin (POMC), it has been suggested that the tumor cells may have a POMC-producing structure. But the tumor cells were positive for proliferating cell nuclear antigen, and this tumor appeared to be a nonfunctional pituitary tumor because no cell atypia or exocytosis was found ultrastructually.
Journal
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- Journal of Equine Science
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Journal of Equine Science 12 (4), 119-126, 2001
Japanese Society of Equine Science
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Details 詳細情報について
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- CRID
- 1390282679346706944
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- NII Article ID
- 130004431189
- 10008559047
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- NII Book ID
- AA11010806
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- ISSN
- 13477501
- 13403516
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- NDL BIB ID
- 6181524
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed