軽症高脂血症患者に及ぼすクロレラ錠剤摂取の影響  [in Japanese] Effect of Chlorella Tablet Ingestion on Mild Hypercholesterolemic Patients  [in Japanese]

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Abstract

非薬物療法で経過観察可能と判断された軽症高脂血症患者20例を対象として,クロレラの投与試験を実施した.患者のうちクロレラの摂取を理解し積極的に協力してくれた11例に,従属栄養的純粋培養で生産されたクロレラを毎日3g, 3か月間投与した(クロレラ摂取群).他の9例は経過観察のみとした(対照群).両群について血清脂質関連の臨床値の推移を観察し,以下の結果を得た. <BR>(1) クロレラ摂取群は,試験前値と比較し1か月と3か月で総コレステロールとLDL-コレステロールが有意に低下した.3か月後のそれぞれの低下率は約6および11%であった.一方,対照群は,試験期間中コレステロールに有意な変化はみられなかった. <BR>(2) 血清脂質関連の臨床値において,クロレラ摂取群でApo A-Iの増加がみられ,動脈硬化指数の(Apo B)/(Apo A-I)が有意な低下を,(LDL-コレステロール)/(HDL-コレステロール)で低下傾向がみられた.その他,対照群でApo Bの一時的な増加がみられた以外は,臨床値に変化はみられなかった. <BR>(3) 試験の前・後で行った不定愁訴に関するアンケート調査から,クロレラの摂取により,一般的な不定愁訴の症状が改善されたことがわかった.また,クロレラの摂取によると思われる副作用は認められなかった.

Chlorella has long been considered to be a healthy food for hypercholesterolemic patients. However, its immediate effect on serum lipid levels has not yet been sufficiently elucidated clinically. We therefore evaluated the serum cholesterol lowering effect of Chlorella, cultured under heterotrophic conditions with glucose as a carbon source, in patients with mild hypercholeste-rolemia. Twenty patients with type II<SUB>a</SUB> hypercholesterolemia were divided into two groups with similar clinical demographics. Eleven patients were each given 3g of Chlorella daily for 3 months (Chlorella group), while nine patients were not (Control group). In the Chlorella group, serum total cholesterol and LDL-cholesterol levels were significantly decreased. The Apo A-I level in serum was increased and atherogenic index (Apo B/Apo A-I) was decreased compared to that before Chlorella ingestion. Improvements in general physical conditions were also observed based on the results of a questionnaire survey. No appreciable side effects were seen during the study period. In the control group, no significant changes were observed during the study period in clinical findings except a temporary increase of the Apo B level in serum. These results indicate that daily ingestion of Chlorella has the potential to lower serum total cholesterol, LDL-cholesterol and atherogenic index in patients with mild hypercholesterolemia.

Journal

  • Nippon Shokuhin Kagaku Kogaku Kaishi

    Nippon Shokuhin Kagaku Kogaku Kaishi 49(6), 395-400, 2002-06-15

    Japanese Society for Food Science and Technology

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008560181
  • NII NACSIS-CAT ID (NCID)
    AN10467499
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1341027X
  • NDL Article ID
    6187386
  • NDL Source Classification
    ZP34(科学技術--食品工学・工業)
  • NDL Call No.
    Z17-126
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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