母乳栄養児および人工栄養児の血清, 尿および糞便中のシアル酸含量  [in Japanese] Differences in the N-Acetylneuraminic Acid Content of Serum, Urine and Feces between Breast-Fed and Formula-Fed Infants  [in Japanese]

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Abstract

分娩後2日から7日までの母乳栄養児および人工栄養児の血清シアル酸および尿, 糞便中のシアル酸含量を測定した。母乳栄養児の血清シアル酸含量は, 41.2±8.58mg/dlであり, 人工栄養児の37.0±5.45mg/dlに比べ有意に高値を示した。また, 母乳栄養児の尿中のクレアチニンに対するシアル酸の含有比は, 0.390±0.079であり, 人工栄養児の0.294±0.081に比べ有意に高値を示した。母乳栄養児の糞便中のシアル酸含量は, 4.59±2.10mg/gと人工栄養児の2.36±1.00mg/gに比べ有意に高値を示した。母乳栄養児の1日当りの尿および糞便中への排泄量は, 18.6mg, 45.9mg, また, 人工栄養児では, 14.0mg, 23.6mgと推定され, いずれも母乳栄養児で高値を示した。薄層クロマトグラフィーの結果, 人工栄養児の糞便および尿には6′-SL画分がほとんど認められなかった。これらの差は, 乳汁からのシアル酸摂取量の差に起因すると考えられる。

The content of N-acetylneuraminic acid (NeuAc) in serum, urine and feces from breast-fed and formula-fed infants at 2-7 days after delivery was determined. The serum content of NeuAc in breast-fed infants was 41.2±8.58mg/dl and that in formula-fed infants was 37.0±5.45mg/dl, the latter being significantly lower (p<0.05). The ratio of NeuAc to creatinine in urine of breast-fed infants was 0.390±0.079 and that of formula-fed infants was 0.294±0.081 (p<0.05). The content of NeuAc in feces of breast-fed infants was 4.59±2.10mg/g fresh feces, and that in formula-fed infants was 2.36±1.00mg/g fresh feces. The amount of NeuAc excreted into urine and feces was 18.6mg/day and 45.9mg/day in breast-fed infants, and 14.0mg/day and 23.6mg/day in formula-fed infants. High-performance thin-layer chromatography revealed little 6′-sialyllactose in urine and feces of formula-fed infants. These differences may be because human milk contains more NeuAc than infant formula.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(1), 43-48, 1995-02-10

    Japan Society of Nutrition and Food Science

References:  34

Codes

  • NII Article ID (NAID)
    10008561611
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    02873516
  • NDL Article ID
    3605262
  • NDL Source Classification
    SC371(小児科学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  NDL  J-STAGE 
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