エタノールの筋弛緩作用に及ぼすセサミンの影響  [in Japanese] Effects of Sesamin on Ethanol-induced Muscle Relaxation  [in Japanese]

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Author(s)

    • 楊 志博 [他] YANG Zhi-bo
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.
    • 諏訪 芳秀 SUWA Yoshihide
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.
    • 平井 孝一 HIRAI Kouichi
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.
    • 豊田 佳子 TOYODA Yoshiko
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.
    • 浅見 純生 ASAMI Sumio
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.
    • 田中 隆治 TANAKA Takaharu
    • サントリー株式会社ヘルスケア事業開発部・健康科学研究室 Health Science Laboratory, Consumer Health Products Department Suntory Ltd.

Abstract

We examined chronological changes in muscle relaxation in ICR mice after p. o. administration of ethanol. The effect of ethanol was found to be dose-dependent. We also carried out an investigation to determine whether or not the muscle relaxation induced in mice by ethanol and acetaldehyde-induced acute toxicity could be suppressed by sesamin. When sesamin (500mg/kg/day) was administered p. o. for 7 or 14 consecutive days, the muscle relaxation induced by ethanol (1.5g/kg, p. o.) was markedly suppressed. Sesamin pretreatment also markedly prevented acetaldehyde-induced acute toxicity (LD<SUB>50</SUB>) in mice, but the ethanol clearance in blood did not show any significant changes. We have not yet determined the mechanism by which sesamin inhibits ethanol-induced muscle relaxation, although the effects seen unlikely to be due to enhanced clearance of ethanol alone.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(2), 103-108, 1995-04-10

    Japan Society of Nutrition and Food Science

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Codes

  • NII Article ID (NAID)
    10008561723
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    02873516
  • NDL Article ID
    3620323
  • NDL Source Classification
    SD0(薬学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  NDL  J-STAGE 
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