オリゴ糖のラットのガラクトサミン肝障害発症に及ぼす影響

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  • Effects of Oligosaccharides on Galactosamine Hepatitis in Rats.
  • オリゴトウ ノ ラット ノ ガラクトサミン カン ショウガイ ハッショウ ニ

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A study was conducted to examine the effects of dietary undigestible oligosaccharides on the development of galactosamine hepatitis in rats. Four-week-old Wistar rats (weight: 55-70g) were fed diets containing 10% oligosaccharides or monosaccharide besides the standard diet for two weeks after one week of prefeeding with the standard diet. On the last day of feeding, the rats were intraperitoneally injected with D-galactosamine solution (800mg/kg body weight), and 20h later the activities of some plasma enzymes were determined to evaluate the effects of oligosaccharides on the development of galactosamine hepatitis. In the first experiment, lactulose, fructooligosaccharide, gentiooligosaccharide, maltooligosaccharide, glucomannooligosaccharide and galactooligosaccharide (T) ((Gal) n-β- (1→6) -Gal-β- (1→4) -Glc) were used. As a result, all of the activities of plasma glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and lactate dehydrogenase in the lackulose group tended to be lower than in the cont ol group, and those in the galactooligosaccharide (T) group were significantly lower than in the other groups. Thus it is considered that the development of galactosamine hepatitis is depressed by dietary galactooligosaccharide (T). However, maltooligosaccharide and glucomannooligosaccharide were shown to have no effect. The results of the second experiment indicated that the development of galactosamine hepatitis is depressed not only by lactulose, raffinose and galactooligosaccharide (B) ((Gal) n-β- (1→4) -Gal-β- (1→4) -Glc) but also by digestible saccharides such as lactose and galactose in the diet.

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