脳卒中易発症性高血圧自然発症ラットの虚血性脳障害に対するセサミンの予防効果  [in Japanese] Prophylactic Effects of Sesamin on Ischemic Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats  [in Japanese]

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Author(s)

Abstract

8週齢のSHRSPにセサミン (市販粉末飼料中に0.5%添加) を8週間投与し, 血圧や体重および大脳皮質におけるフリーラジカル障害に及ぼす影響を検討した。<BR>1) WKYでもSHRSPでも, 血圧や体重への影響は認められなかった。<BR>2) SHRSPの対照群では脳重量の増加がみられ, 半数に脳軟化巣が認められたが, セサミン投与群では脳重量の増加はなく, 脳卒中病変の発生も認められなかった。<BR>3) SHRSPの大脳皮質では尿酸値の著しい上昇がみられたが, これはセサミン投与により明らかに抑制された。<BR>4) SHRSPのセサミン投与群ではSOD活性は対照群に比べ低値であった。<BR>5) SHRSPのセサミン投与群ではNa/K-ATPase活性が対照群に比べ高値であった。<BR>以上の結果より, セサミンはSHRSPの大脳皮質においてキサンチン-キサンチンオキシダーゼ系で産生されるフリーラジカルを速やかに捕捉することにより, 虚血による障害を防止すると考えられる。

As part of a basic study on the prevention of ischemic cerebral injury, sesamin (5g/kg Funabashi SP diet) was administered to stroke-prone spontaneously hypertensive rats (SHRSP) for 8 weeks from 8 weeks of age, and pathological and biochemical changes in the cerebral cortex were examined and compared with those in normotensive Wistar-Kyoto rats (WKY). In the control SHRSP, cerebral softening was found in 4 of 8 rats (50%), whereas no pathological changes were evident in sesamin-treated rats. In control SHRSP, the uric acid content of the cerebral cortex was extremely high in comparison with that in control WKY, but it was significantly lower (p<0.05) in sesamin-treated SHRSP. On the other hand, superoxide dismutase (SOD) activity was lower (p<0.05) and Na/K-ATPase was higher (p<0.05) in sesamin-treated SHRSP than in WKY. These results indicate that lipid peroxidation caused by free radicals is an important factor in ischemic cerebral injury, and that sesamin plays an important role in the scavenging of free radicals, thus preventing cerebral softening in SHRSP.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(3), 189-193, 1995-06-10

    Japan Society of Nutrition and Food Science

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Codes

  • NII Article ID (NAID)
    10008562481
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02873516
  • NDL Article ID
    3619513
  • NDL Source Classification
    SC271;SC351
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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