ユーグレナ (Euglena gracilis Z) 飼料で飼育したSHRSP (脳卒中易発症性高血圧自然発症ラット) の血管組織アンギオテンシン I-変換酵素活性の低下と血管壁の肥厚抑制  [in Japanese] Lowering of the Vascular Tissue Angiotensin I-Converting Enzyme Activity and Suppression of the Hypertrophy of Vascular Wall in Stroke-Prone Spontaneously Hypertensive Rats Fed Euglena (Euglena gracilis Z) Diet  [in Japanese]

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Abstract

脳卒中易発症性高血圧自然発症ラット (SHRSP) にユーグレナ (<I>Eugtena gracitis</I> Z) をタンパク源とした飼料を5週齢から20週齢まで投与し血清ならびに血管組織ACE活性と大動脈エラスチン量に及ぼす影響をACE阻害剤のカプトプリルと比較検討した。<BR>1) 5週齢からユーグレナ飼料を投与したSHRSPの血圧は対照群と変わらなかったが, カプトプリルを投与したSHRSPでは血圧上昇は抑制された。<BR>2) ユーグレナ群の血清ACE活性は, 対照群と変わらなかったが, カプトプリル群では対照群より高値を示した。<BR>3) 胸部大動脈ACE活性は対照群に比ベユーグレナ群, カプトプリル群で有意に低値であった (p<0.05)。しかし, 腸間膜動脈ACE活性は対照群に比べ両群とも低値であったが有意な差ではなかった。<BR>4) ユーグレナ群, カプトプリル群の大動脈比体重は対照群より有意に小さく (p<0.05), 大動脈エラスチン量も高値を示した。<BR>以上の結果より, ユーグレナ飼料によるSHRSPの血管壁の肥厚抑制や弾性の低下の抑制は血管組織ACE活性の阻害を介していると考えられた。それが, 脳血管疾患の発症抑制や遅延につながり延命をもたらすものと推察した。

From 5 to 20 weeks of age, stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet, containing dry <I>Euglena</I> cells (<I>Euglena gracilis</I> Z: at 30.4% in diet) as a protein source (<I>Euglena</I> diet) and its effects on the activity of angiotensin I-converting enzyme (ACE) in serum and vascular tissues and on the aortic elastin content were studied. The effects of captopril, an ACE inhibitor, were also studied for comparison. 1) The <I>Euglena</I> diet had no significant effect on blood pressure. In the SHRSP administered captopril from 5 weeks of age, blood pressure elevation was inhibited. 2) The serum ACE activity in SHRSP fed the <I>Euglena</I> diet showed no difference from that in the control group fed a commercial stock chow. In the SHRSP administered captopril, the serum ACE activity was enhanced. 3) The thoracic aorta ACE activity was lowered more (p<0.05) in both the <I>Euglena</I>-fed and captopril-treated groups than in the control group. The mesenteric artery ACE activ ties in both experimental groups were somewhat lower than that in the control group. 4) The ratio of aorta weight to body weight was significantly lower (p<0.05) in the <I>Euglena</I>-fed and captopril-treated groups than in the control group. Higher levels of aortic elastin were observed in the <I>Euglena</I>-fed and captopril-treated groups (p<0.05). These results suggest that suppression of hypertrophy and reduction in elasticity of the vascular wall in SHRSP fed a <I>Euglena</I> diet are due to an inhibitory effect on vascular tissue ACE activity.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(3), 203-208, 1995-06-10

    Japan Society of Nutrition and Food Science

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Codes

  • NII Article ID (NAID)
    10008562540
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02873516
  • NDL Article ID
    3619243
  • NDL Source Classification
    SC226;SC271
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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