カゼインのトリプシン分解物のラットにおける脳卒中予防効果に関する実験的研究  [in Japanese] Studies on Preventive Effect of Casein Tryptic Hydrolysate on Cerebral Apoplexy in Rats  [in Japanese]

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Author(s)

Abstract

循環器疾患モデル動物のSHRSPに対して, カゼイントリプシン加水分解物配合飼料を摂食させ, 循環器疾患の予防効果を試験し, 以下の結果を得た。<BR>1) カゼイントリプシン加水分解物は脳卒中の発症を抑制した。病理学的には脳の浮腫を有意に抑制し, 心臓の肥大を抑制する傾向を示した。<BR>2) カゼイントリプシン加水分解物は脳血管障害による死亡を防ぎ, 延命効果を示した。

The preventive effect of tryptic hydrolysate of milk casein against cardiovascular disease was studied in stroke-prone spontaneously hypertensive rats (SHRSP). Blood pressure, body weight, brain weight, heart weight, survival rate, incidence of stroke and pathological data after oral administration of the hydrolysate were investigated. An amino acid mixture with the same composition as that of the hydrolysate was given to a control group. Thirty week feeding with the 10% hydrolysate significantly retarded the increase of brain weight due to cerebral edema and the incidence of stroke. In addition, the diet tended to reduce the increase of heart weight due to cardiac hypertrophy caused by hypertension. These results suggest that this tryptic hydrolysate is useful for preventing cardiovascular disease in rats and increasing their survival rate.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(4), 307-311, 1995-08-10

    Japan Society of Nutrition and Food Science

References:  24

  • <no title>

    YAMORI Y.

    Jpn. Circ. J. 38, 1095, 1974

    Cited by (1)

  • <no title>

    YAMORI Y.

    Handbook of Hypertension 240, 1984

    Cited by (1)

  • <no title>

    YAMORI Y.

    Atheroscierosis 42, 15, 1982

    Cited by (1)

  • <no title>

    YAMORI Y.

    Jpn. Heart J. 18, 602, 1977

    Cited by (1)

  • <no title>

    YAMORI Y.

    Prevention of Cardiovascular Diseases : An Approach to Active Long Life 163, 1987

    Cited by (2)

  • <no title>

    YAMORI Y.

    New Horizon in Preventing Cardiovascular Diseases 1, 1989

    Cited by (1)

  • <no title>

    YAMORI Y.

    Acta Pathol. Jpn. 39, 683, 1989

    Cited by (1)

  • <no title>

    OKAMOTO K.

    Jpn. Circ. J. 27, 282, 1963

    Cited by (2)

  • <no title>

    YAMORI Y.

    Handbook of Hypertension 4, 224, 1984

    Cited by (1)

  • <no title>

    YAMORI Y.

    Prophylactic Approach to Hypertensive Diseases 573, 1979

    Cited by (1)

  • <no title>

    YAMORI Y.

    New Trends in Arterial Hypertension (INSERM Symposium 17, 305, 1981

    Cited by (1)

  • <no title>

    YAMORI Y.

    Magnesium 1, 163, 1982

    Cited by (1)

  • <no title>

    YAMORI Y.

    Sulfur Amino Acids : Biochemical Aspects 103, 1983

    Cited by (1)

  • <no title>

    YAMORI Y.

    Nutritional Prevention of Cardiovascular Diseases 37, 1984

    Cited by (1)

  • <no title>

    YAMORI Y.

    J. Hypertens. 4(Suppl. 3), S449, 1986

    Cited by (1)

  • <no title>

    KARAKI H.

    Comp. Biochem. Physiol. 96C, 367, 1990

    Cited by (3)

  • <no title>

    村上梅司

    月刊フードケミカル 1988(11), 39, 1988

    Cited by (1)

  • <no title>

    関谷宗郎

    栄食誌 45(6), 513, 1992

    Cited by (1)

  • <no title>

    SVEDAS J. V.

    Anal. Biochem. 101, 188, 1980

    Cited by (1)

  • <no title>

    奥山典生

    タンパク質化学1 302, 1969

    Cited by (1)

  • <no title>

    川口桂三郎

    農芸化学実験書 1, 120, 1957

    Cited by (1)

  • <no title>

    IKEDA K.

    Lab. Anim. 25, 25, 1991

    Cited by (1)

  • <no title>

    AKIGUCHI I.

    Jpn. Heart J. 19, 615, 1978

    Cited by (2)

  • <no title>

    OHTA Y.

    Genet. Hypertens. 218, 393, 1992

    Cited by (1)

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008562808
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02873516
  • NDL Article ID
    3631930
  • NDL Source Classification
    SC226(衛生学・公衆衛生--食品衛生・栄養学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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