グアガムおよびコレスチラミンがラット血漿コレステロール濃度と糞排泄ステロイドに及ぼす影響の比較  [in Japanese] Comparative Effects of Guar Gum and Cholestyramine on Plasma Cholesterol and Fecal Steroid Excretion in Rats  [in Japanese]

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Abstract

水溶性繊維であるグアガムの血漿コレステロール低下の作用機序を知る目的で, 胆汁酸の排泄を促進するコレスチラミンとグアガムの血漿コレステロール濃度に及ぼす影響を比較した。食餌中コレスチラミン含量を1, 2, 4, 6, 8%, グアガム含量を5%とし, グアガム群の摂食量に対するpair-feedingで, 1日2回1時間のmealfeedingで, 10週齢SD系雄ラットを2週間飼育した。コレスチラミンは用量依存的に糞中胆汁酸, 中性ステロイドの排泄量を増加させたが, 血漿コレステロール濃度を有意には低下させなかった。グアガム群の糞中排泄ステロイド量は1%コレスチラミン群の排泄量に相当したにもかかわらず, グアガム群の血漿コレステロール濃度は有意に低下した。これらの結果から, 糞中ステロイドを増加させるだけではコレステロール非負荷ラットの血漿コレステロール濃度を有意に低下させることは難しいこと, グアガムの血漿コレステロール低下作用をステロイド排泄では説明できないことが示された。

The effects of guar gum (5% in the diet) and various levels of cholestyramine (1%, 2%, 4%, 6% or 8% in the diet) on the plasma cholesterol level and fecal steroid excretion were examined in male rats fed a cholesterol-free feed for 14 days. Cholestyramine increased dose-dependently the fecal excretion of bile acid and neutral steroid, but the hypocholesterolemic effect of cholestyramine was not significant. The plasma cholesterol level in rats fed the guar gum diet was significantly lower than that in rats fed a cellulose diet (control), although fecal steroid excretion in rats fed the guar gum diet was comparable to that in rats fed the 1% cholestyramine diet. These results suggest it is unlikely that the plasma cholesterol level is decreased significantly by an increase of fecal steroid excretion alone in rats fed a cholesterol-free diet, and that some other mechanism contributes to the hypocholesterolemic effect of guar gum.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(4), 313-317, 1995-08-10

    Japan Society of Nutrition and Food Science

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Codes

  • NII Article ID (NAID)
    10008562833
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02873516
  • NDL Article ID
    3631935
  • NDL Source Classification
    SC226(衛生学・公衆衛生--食品衛生・栄養学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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