Comparative Effects of Guar Gum and Cholestyramine on Plasma Cholesterol and Fecal Steroid Excretion in Rats.

• TAKEHISA Fumiyuki

  Department of Home Economics, Miyagi-Gakuin Women's College

Bibliographic Information

Other Title

• グアガムおよびコレスチラミンがラット血しょうコレステロール濃度と糞排せつステロイドに及ぼす影響の比較
• グアガム オヨビ コレスチラミン ガ ラット ケッショウ コレステロール ノウ

Abstract

The effects of guar gum (5% in the diet) and various levels of cholestyramine (1%, 2%, 4%, 6% or 8% in the diet) on the plasma cholesterol level and fecal steroid excretion were examined in male rats fed a cholesterol-free feed for 14 days. Cholestyramine increased dose-dependently the fecal excretion of bile acid and neutral steroid, but the hypocholesterolemic effect of cholestyramine was not significant. The plasma cholesterol level in rats fed the guar gum diet was significantly lower than that in rats fed a cellulose diet (control), although fecal steroid excretion in rats fed the guar gum diet was comparable to that in rats fed the 1% cholestyramine diet. These results suggest it is unlikely that the plasma cholesterol level is decreased significantly by an increase of fecal steroid excretion alone in rats fed a cholesterol-free diet, and that some other mechanism contributes to the hypocholesterolemic effect of guar gum.

Journal

• Nippon Eiyo Shokuryo Gakkaishi

  Nippon Eiyo Shokuryo Gakkaishi 48 (4), 313-317, 1995

  Japan Society of Nutrition and Food Science

Keywords

• dietary fiber
• cholestyramine
• fecal steroid excretion
• plasma cholesterol

Details

• CRID: 1390282681269077504
• NII Article ID: 10008562833
• NII Book ID: AN00311992
• DOI: 10.4327/jsnfs.48.313
• ISSN: 18832849
• ISSN: 02873516
• NDL BIB ID: 3631935
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3631935
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed