脳卒中易発症性高血圧自然発症ラットの脂質代謝に及ぼすDHA強化ユーグレナ (Euglena gracilis Z) の影響  [in Japanese] Effect of Euglena (Euglena gracilis Z) Enriched with Docosahexaenoic Acid on Lipid Metabolism in Stroke-Prone Spontaneously Hypertensive Rats  [in Japanese]

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Abstract

DHAをユーグレナ細胞中に蓄積させたDHA強化ユーグレナがSHRSPの血清ならびに肝臓の脂質代謝に及ぼす影響について検討した。<BR>8週齢の雄性SHRSPを使用し, DHA強化ユーグレナと対照食より調製したDHA-ユーグレナ飼料を12週間飲水とともに自由摂取させたところ次の結果が得られた。<BR>1) SHRSPの成長への影響はまったく認められなかった。また, 明確な血圧上昇抑制作用も観察されなかった。<BR>2) 血清総コレステロール, リン脂質, ならびに血清apoA-I, A-IV, BそしてE, いずれも有意な減少が認められ, 脂質低下作用が示唆された。<BR>3) 血清各リポタンパク分画への脂質およびアポタンパク類の分布を詳細に調べたところ, 血清脂質低下作用は, VLDL, LDLおよびHDL, すべてのリポタンパクの減少に基づくものであった。<BR>4) 肝臓においては, 単位体重当りの肝臓重量の有意な上昇が認められるとともに, リン脂質含量の有意な減少が観察された。しかし, ミクロソーム分画のコレステロール代謝関連酵素活性への有意な影響は観察されなかった。

Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a docosahexaenoic acid (DHA) -<I>Euglena</I> diet which was prepared from dry cells of <I>Euglena</I> gracilis Z enriched with DHA as a major protein source from 8 weeks until 20 weeks of age. The effects of the DHA-<I>Euglena</I> diet on lipid metabolism in the serum and liver were then investigated and the results obtained were as follows: 1) The DHA-<I>Euglena</I> diet had no effect on growth. Moreover, no marked change in blood pressure was observed. 2) Serum concentrations of total cholesterol and phospholipid were significantly lower than those in the control group. In addition, the serum levels of apolipoproteins A-I, A-IV, B and E were also significantly lower than those in the control group. These results suggested a hypolipidemic effect of the DHA-<I>Euglena</I> diet. 3) The hypolipidemic effect of the DHA-<I>Euglena</I> diet was due to decreases in very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), judging from the distributions of lipid and apolipoproteins among the various lipoprotein fractions. 4) The relative weight of the liver to total body weight was significantly elevated and the hepatic content of phospholipid was significantly decreased compared with the control group. However, there was no significant change in the activities of microsomal cholesterol 7α-hydroxylase and acyl-CoA: cholesterol acyltransferase.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(4), 319-324, 1995-08-10

    Japan Society of Nutrition and Food Science

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  • DHA : 基礎と効能  [in Japanese]

    YAZAWA KAZUNAGA

    Farumashia 31(1), 42-46, 1995

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Codes

  • NII Article ID (NAID)
    10008562856
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    02873516
  • NDL Article ID
    3632004
  • NDL Source Classification
    SC226(衛生学・公衆衛生--食品衛生・栄養学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  NDL  J-STAGE 
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