食環境因子による血清リポタンパク質代謝の変動機構に関する研究  [in Japanese] Changes in Serum Lipoprotein Metabolism Induced by Dietary Protein and Xenobiotics  [in Japanese]

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Author(s)

    • 小田 裕昭 ODA Hiroaki
    • 名古屋大学農学部応用生物科学科 Department of Applied Biological Sciences, School of Agricultural Sciences, Nagoya University

Abstract

It is well known that dietary xenobiotics and protein nutrition affect cholesterol and serum lipoprotein metabolism, although these precise mechanism has not been fully clarified. Treatment of rats with xenobiotics such as polychlorinated biphenyls (PCB) resulted in hyper-α-lipoproteinemia, characterized by an increase of apolipoprotein A-I (apo A-I) and replacement of apo E by apo A-I. Dietary PCB increased the hepatic levels of mRNA for apo A-I and HMG-CoA reductase. In hepatocyte culture, a direct effect of PCB on hepatocytes was revealed. The dietary level of protein regulated the expression of the liver apo A-I gene transcriptionally in a liver-specific manner. Soy protein isolate (SPI) decreased the cholesterol level of very-low-density lipoproteins and of high-density lipoproteins in comparison with casein. SPI lowered the level of apo E-rich lipoproteins, and then decreased that of apo A-I-rich lipoproteins. The hepatic apo A-I mRNA level was decreased by SPI, and elevated by addition of methionine. These results demonstrate that dietary xenobiotics and protein are regulators of apo A-I gene expression and the serum level of high-density lipoproteins.

Journal

  • Nippon Eiyo Shokuryo Gakkaishi

    Nippon Eiyo Shokuryo Gakkaishi 48(5), 357-364, 1995-10-10

    Japan Society of Nutrition and Food Science

References:  58

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008562970
  • NII NACSIS-CAT ID (NCID)
    AN00311992
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02873516
  • NDL Article ID
    3645073
  • NDL Source Classification
    SC226(衛生学・公衆衛生--食品衛生・栄養学)
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-53
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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