スギ花粉症とoral allergy syndrome(OAS)  [in Japanese] Oral Allergy Syndrome in Patients with Japanese Cedar Pollinosis  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

花粉症患者のうち,新鮮な果実や野菜を摂取後に口唇の発赤•浮腫や咽頭掻痒感などを生じることがある.これをoral allergy syndrome(OAS)とよび,北欧ではシラカンバ花粉症にリンゴなどのバラ科果実によるOASの合併が知られている.一方,日本でもっとも多いスギ花粉症との関係についての報告はほとんどない.今回スギ花粉症患者の中で,問診からOASと診断された23例を対象に検討を行った.<br>症状は个例,咽頭の掻痒感やイガイガ感であり,喉頭浮腫やアナフィラキシー症状を訴える例は認めなかった.<br><br>原因果実としては,メロンがもつとも多く,次いでリンゴ,モモ,キウイの順であった.シラカンバ花粉症とバラ科果実のような明らかな関係は認められなかった.多くの例で2個以上の果実に過敏性を認めた.<br>特異IgE抗体価の測定では,スギ花粉の他にシラカンバ花粉に対する特異IgE抗体価陽性例を多く認めた.一方,果実に対するIgE抗体価では,リンゴの陽性率が高いのに比べ,メロンでは全例陰性であり,新鮮な果汁を用いた皮膚テストでの確認が必要と思われた.<br>スギ花粉症患者でOASの合併が疑われた場合にはシラカンバ花粉とリンゴに対するIgE抗体価の測定が有用と思われた.<br>今回,問診ではじめてOASに気づいた例もあり,問診を注意深く行うことでOASを合併した患者の頻度が高くなるものと思われた.

Patients with pollinosis sometimes complain of oral symptoms (itching and tingling with or without edema of the lips, mouth and tongue) after eating fresh fruits and vegetables. This condition has been termed Oral Allergy Syndrome (OAS). Twenty three patients with Japanese cedar pollinosis and OAS for fresh fruits and vegetables were included in this study. Their mean age was 31.3 years (range=5 to 62).<br>The fruits that caused OAS in these patients included melon, apple, peach, and kiwi fruit. Most patients with OAS exhibited hypersensitivity to more than two foods.<br>Specific IgE antibodies to inhaled allergens of mite, Japanese cedar pollen, birch pollen, melon, apple, peach, and kiwi were evaluated using the Pharmacia CAP system. Eleven of the 16 subjects with specific IgE antibodies for birch pollen, did not suffer symptoms during the birch and alder pollen season.<br>In subjects with specific IgE antibodies for fruits, 13 out of 20 patients showed specific IgE antibodies for apple, and 8 out of 9 patients with OAS for apples were also positive for specific IgE antibodies for apples. On the other hand, 17 patients had no specific IgE antibodies for melon, and only two patients and one patient showed specific IgE antibodies for kiwi fruit and peach, respectively.<br>These results suggest that the evaluation of specific IgE antibodies to birch pollen and apple may be useful for diagnosing OAS in patients with Japanese cedar pollinosis.

Journal

  • Nippon Jibiinkoka Gakkai Kaiho

    Nippon Jibiinkoka Gakkai Kaiho 103(3), 199-205, 2000-03-20

    The Oto-Rhino-Laryngological Society of Japan, Inc.

References:  22

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008574576
  • NII NACSIS-CAT ID (NCID)
    AN00191551
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00306622
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top