ラマトロバンと抗ヒスタミン薬の併用効果

• 成田 慎一郎

  市立函館病院耳鼻咽喉科

• 白崎 英明

  札幌医科大学耳鼻咽喉科学教室

• 黒瀬 誠

  市立函館病院耳鼻咽喉科

• 小林 一豊

  市立函館病院耳鼻咽喉科

• 氷見 徹夫

  札幌医科大学耳鼻咽喉科学教室

書誌事項

タイトル別名

• Ramatroban Produces Beneficial Effects in Nasal Symptoms of Patients with Perennial Allergic Rhinitis When Used in Combination with an Antihistamine.
• ヤクブツ ラマトロバン ト コウヒスタミンヤク ノ ヘイヨウ コウカ

抄録

We investigated the effects of combination therapy with thromboxane A₂ receptor antagonist (TxA₂ RA: Ramatroban) and an antihistamine (Clemastine Fumarate) in patients with perennial allergic rhinitis. There was no significant difference in the three groups: combination group (n=20), the TxA₂ RA (only Ramatroban) group (n=18) and the antihistamine (only Clemastine Fumarate) group (n=9) in terms of global improvement rating. Improvement was significantly better in the combination group compared to that in the TxA₂ RA group two weeks after the start of administration (p<0.05). Moreover, intranasal rhinoscopic findings showed the mean nasal secretion score was significantly decreased in both the combination and TxA₂ RA groups (p<0.05).<br>These findings suggest that TxA₂ (Ramatroban) in combination with an antihistamine has beneficial effects on rhinorrhea in patients with perennial allergic rhinitis.

収録刊行物

• 耳鼻咽喉科臨床

  耳鼻咽喉科臨床 95 (6), 653-658, 2002

  耳鼻咽喉科臨床学会

キーワード

• Ramatroban
• allergic rhinitis
• combination
• antihistamine
• thromboxane A₂

詳細情報

• CRID: 1390282679236165888
• NII論文ID: 10008575190
• NII書誌ID: AN00107089
• DOI: 10.5631/jibirin.95.653
• ISSN: 18844545
• ISSN: 00326313
• NDL書誌ID: 6177658
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6177658
• Web Site: https://search.jamas.or.jp/link/ui/2002231937
• 本文言語コード: ja
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可