ラマトロバンと抗ヒスタミン薬の併用効果  [in Japanese] Ramatroban Produces Beneficial Effects in Nasal Symptoms of Patients with Perennial Allergic Rhinitis When Used in Combination with an Antihistamine  [in Japanese]

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Author(s)

Abstract

We investigated the effects of combination therapy with thromboxane A<sub>2</sub> receptor antagonist (TxA<sub>2</sub> RA: Ramatroban) and an antihistamine (Clemastine Fumarate) in patients with perennial allergic rhinitis. There was no significant difference in the three groups: combination group (n=20), the TxA<sub>2</sub> RA (only Ramatroban) group (n=18) and the antihistamine (only Clemastine Fumarate) group (n=9) in terms of global improvement rating. Improvement was significantly better in the combination group compared to that in the TxA<sub>2</sub> RA group two weeks after the start of administration (p<0.05). Moreover, intranasal rhinoscopic findings showed the mean nasal secretion score was significantly decreased in both the combination and TxA<sub>2</sub> RA groups (p<0.05).<br>These findings suggest that TxA<sub>2</sub> (Ramatroban) in combination with an antihistamine has beneficial effects on rhinorrhea in patients with perennial allergic rhinitis.

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 95(6), 653-658, 2002-06-01

    The Society of Practical Otolaryngology

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008575190
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00326313
  • NDL Article ID
    6177658
  • NDL Source Classification
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL Call No.
    Z19-421
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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