上咽頭癌に対する放射線・持続動注化学療法  [in Japanese] Intra-arterial chemotherapy combined with radiotherapy for nasopharyngeal carcinoma  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

上咽頭は, 解剖学的に根治手術困難な部位である事から, 上咽頭癌に対して手術以外の様々な治療法が試まれてきた.当科においては, 様々な方法にて化学療法を併用し, 1990年からは, 上咽頭癌の制御の為に浅側頭動脈からの動注化学療法を積極的に行い, 放射線療法と併用している.<BR>局所制御効果が高い治療法という結果を得たが, 上咽頭や遠隔転移の制御は完全なものとはいえず, 制御率の向上とともに, 上咽頭及び遠隔転移巣への有効な併用化学療法の展開が必要と思われる.

From November 1972 to December 1999, we have experienced 17 previously untreated patients of nasopharyngeal carcinoma who were treated with concurrent radiotherapy and intra-arterial chemotherapy. Histologically, all the patients suffered from squamous cell carcinoma.<BR>We have used 5-FU or BLM or CBDCA for each patient. A five-year survival rate by the Kaplan-Meier method was 73%: stageII (n=9), 71%; stageIII (n=7), 71%; stageIV (n=1), 100%, and: T1 (n=9), 80%; T2 (n=2), 50%; T3 (n=5), 60%; T4 (n=1), 100%. We had relatively good local control in the advanced cases. Four cases were dead within 5 years; 3 were due to local recurrence and 1 was distant metastasis.

Journal

  • Stomato-pharyngology

    Stomato-pharyngology 13(3), 359-365, 2001-06-01

    Japan Society of Stomato-pharyngology

References:  11

Codes

Page Top