カプサイシン入りガムを使用した嚥下訓練  [in Japanese] Swallowing Rehabilitation Using Chewing Gum Containing Capsaicin  [in Japanese]

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Abstract

成人10名にカプサイシンを10<sup>-6</sup> mol/mlに溶解させた蒸留水を口腔内に噴霧し,噴霧前と噴霧後の唾液中に含まれるサブスタンスP(以下SPと省略)の濃度を測定した。同様に,成人10名にカプサイシンを1枚につき6×10<sup>-8</sup> mol程度含有した市販のガムを使用して,ガムを噛む前と噛んだ後の唾液中SPの濃度も測定した。その結果,カプサイシン投与後,ガムを噛んだ後,ともに有意な唾液中のSPの上昇を認めた。同様に筋萎縮性側索硬化症,パーキンソン病,眼咽頭型筋ジストロフィー症,ギランバレー症候群,脊髄小脳変性症患者でも,カプサイシン投与でSPが有意に上昇した。したがって,カプサイシン入りガムを噛むことで咀嚼・嚥下の訓練になり,さらに唾液中のSPが上昇することで嚥下反射が起こりやすくなることが期待できる。嚥下訓練にカプサイシン入りガムを用いるのは有用と考えられた。

Distilled water containing of capsaicin 10<sup>-6</sup> mol/ml was sprayed into oral cavity obtain adults, and the concentration of substance P (SP) in the saliva was measured before and after the spray. Similary, the concentration of SP in the saliva before and after chewing gum which contained about 6×10<sup>-8</sup> mol per piece of capsaicin was also measured for ten adults. A significant rise in SP in the saliva after the capsaicin administration in both procedures was seen.<br>SP significantly increased in the saliva of dysphagic patients with amyotrophic lateral sclerosis, Parkinson disease, oculopharyngeal muscular dystrophy, Guillain-Barre syndrome, and spinocerebellar degeneration after capsaicin administration. Therefore, it can be said that chewing gum is an adequate treatment for mastication and swallowing, and that the increase in SP in the saliva leads to greater sensitive trigger for the swallowing reflex.

Journal

  • Nihon Kikan Shokudoka Gakkai Kaiho

    Nihon Kikan Shokudoka Gakkai Kaiho 53(3), 285-288, 2002-06-10

    The Japan Broncho-esophagological Society

References:  5

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008579670
  • NII NACSIS-CAT ID (NCID)
    AN00187474
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00290645
  • Data Source
    CJP  CJPref  J-STAGE 
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