3主徴と副鼻腔炎を伴うyellow nail症候群の1例 : クラリスロマイシンによる治療  [in Japanese] Yellow Nail Syndrome with Major Triad and Sinusitis Treated with Clarithromycin  [in Japanese]

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Abstract

54歳,女性.約5年前から,すべての指趾の爪甲が黄色に肥厚していることに気付いていた.気管支拡張症と顔面・下肢の一過性のリンパ浮腫を合併しており,3主徴が揃った典型的なyellow nail症候群と診断した.さらに,慢性副鼻腔炎の合併も証明された.クラリスロマイシンの内服により気管支拡張症と副鼻腔炎は改善し,ステロイド外用薬と活性化ビタミンD<sub>3</sub>外用薬の塗布により,正常爪の出現をみている.文献的に副鼻腔炎の合併は20~25%にみられ,本症候群の主要な病変の1つと考えられる.マクロライド系抗生剤による本症の治療に関する報告はないが,試みるべき治療法と考え,その奏功機序を考察した.

We report a 54-year-old female with yellow nail syndrome (YNS). The patient first noticed hypertrophic, yellowish nails with slow growth five years ago and then was diagnosed with bronchiectasis two years later. She has sometimes also experienced lymphedma on her face and inferior limbs, so she has the triad sign of YNS. Chronic sinusitis was also associated. As sinusitis has been reported to be accompanied with 20~25% cases of YNS, it should be emphasized that sinusitis is one of the characteristic changes of YNS. Oral therapy with clarithromycin resolved the pleural effusion and sinusitis, and topical therapy with steroids and vitamin D<sub>3</sub> improved the nail changes. The present case indicates that macrolide antibiotics should be tried for the treatment of YNS, although there have been no reports showing the therapeutic effects of this medication on YNS.

Journal

  • The Japanese Journal of Dermatology

    The Japanese Journal of Dermatology 112(3), 261-265, 2002-03-20

    Japanese Dermatological Association

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008584572
  • NII NACSIS-CAT ID (NCID)
    AN00196602
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021499X
  • NDL Article ID
    025120759
  • NDL Call No.
    Z19-202
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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