Bromodermaの1例  [in Japanese] A Case Report of Bromoderma  [in Japanese]

Access this Article

Author(s)

Abstract

臭化ナトリウムの投与により発症したBromodermaの一例を経験した.症例は6歳,男児.症候性てんかんに対してクロナゼパムと臭化ナトリウムの内服治療を受けていた.右頬部に境界明瞭で周囲に紅暈のある円形ないし不整形な局面で膿疱,痂皮を伴う皮疹が出現した.検査所見では血中臭化物濃度が150 mg/dlと上昇.細菌,真菌,非定型抗酸菌培養検査はすべて陰性.病理組織像では表皮の肥厚,偽癌性増殖,真皮内の著明な好中球の浸潤と赤血球の血管外漏出,開大した毛包漏斗部内の膿瘍の形成を認めた.以上より本症例をBromodermaと診断.臭化ナトリウムの内服中止により約2カ月で皮疹は改善した.

A 6-year-old boy visited our department with a one month history of a skin lesion on the face. He had been taking sodium bromide, 1.2 g/day, as an anticonvulsant for three months prior to the onset of the lesion. Physical examination showed erythrmatous, pustular, and nodular lesions with scaly crusts on the face. The serum bromide level was highly increased (150 mg/dl, normal 0 to 0.5 mg/dl). Cultures for bacteria, fungi, and atypical acid-fast bacilli were all negative. A skin biopsy specimen showed epidermal hyperplasia with downward proliferation of the epidermis. In the dermis, there was a dense diffuse infiltrarion of neutrophils accompanied by extensive extravasations of erythrocytes and abscesses within dilated infundibula. The diagnosis of bromoderma was made and sodium bromide was discontinued. The skin lesions healed leaving minimal scarring in two months.

Journal

  • The Japanese Journal of Dermatology

    The Japanese Journal of Dermatology 112(4), 393-399, 2002-04-20

    Japanese Dermatological Association

References:  26

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008584797
  • NII NACSIS-CAT ID (NCID)
    AN00196602
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021499X
  • NDL Article ID
    025120997
  • NDL Call No.
    Z19-202
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top