サイトカインから見た侵襲に対する生体反応 SIRS,CARS,サイトカイン

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タイトル別名
  • Host response against insult
  • ―SIRS, CARS, サイトカイン―

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We reviewed the host response to the invasion from the viewpoint of inflammatory cytokines and endothelial injury. We found the elevation circulating cytokines, IL-6 and IL-10, in patients with severe heat injuries, cerebrovascular diseases, and severe brain damage, while there was no signs of apparent inflammation. The host response to insult is thought to be the action of defense and be physiological, but the response of various cytokines might be controlled by the central nervous system. However, the strong course like HPA axis as seen in the induction of the hormones was unclear for now, and the reviewing of a future seemed to be necessary about whether these cytokine responses are from the central nervous system or from the peripheral sites. Moreover, single nucleotide polymorphisms (SNP) in various mediators including inflammatory cytokines were discovered recently, thus it does a very subtly controlled host defense response about the whole body inflammatory reaction in individuals.

収録刊行物

  • 蘇生

    蘇生 20 (2), 126-130, 2001

    日本蘇生学会

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