書誌事項
- タイトル別名
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- Antithrombotic Effect of Glycosaminoglycan-modified Urinary Thrombomodulin (GAG-UTM) on Tissue factor-induced DIC Rats
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The anticoagulant and antithrombotic effects of a glycosaminoglycan-modified urinary thrombomodulin (GAG-UTM) expressed in C-127 cells were investigated.<br>Among several species of blood tested, GAG-UTM induced a 2-fold prolongation at 0.24μg/ml in human whole blood clotting time.<br>Following the injection of 125I-fibrinogen, the rat was infused with Tissue factor (TF) 30mg/kg/hr intravenously (i.v.), and the macro-autoradiogram was conducted. Marked accumulations of 125I-fibrin comprising microthrombi were observed in major organs such as kidney, spleen, liver and lung. The tissue/blood (T/B) ratio of the radioactivity was used to indicate the distribution of thrombi. TF infusion gave rise to 1.1 through 4.7 in the T/B values.<br>In the above treatment, i.v. infusion of GAG-UTM (10 to 300μg/kg/hr) dose-dependently decreased the T/B values. Moreover, significant improvement of the platelet counts and plasma fibrinogen levels were induced by GAG-UTM administration (more than 30μg/kg/hr).<br>Those results indicate that GAG-UTM shows an excellent inhibitory effect on TF-induced thrombus formation, and it markedly normalizes the bleeding tendency caused by TF-infusion.<br>It seems that GAG-UTM may be a potent antithrombotic agent without affecting bleeding tendency in clinical use.
収録刊行物
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- 日本血栓止血学会誌
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日本血栓止血学会誌 6 (3), 183-191, 1995
一般社団法人 日本血栓止血学会
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詳細情報 詳細情報について
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- CRID
- 1390001204451604608
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- NII論文ID
- 130004262447
- 10008597164
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- NII書誌ID
- AN10353762
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- ISSN
- 18808808
- 09157441
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可