Expression of PCNA, Basic Fibroblast Growth Factor, FGF-receptor and Vascular Endothelial Growth Factor in Adenomas and Carcinomas of Human Colon

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Abstract

This study was designed to clarify the role of growth factors and vascular proliferation in the growth of colon tumor. On immunohistochemical observation, the ratios of positive cells for PCNA, bFGF and VEGF in carcinomas and adenomas were higher than in non-neoplastic mucosa. On reverse transcriptasepolymerase chain reaction (RT-PCR) study, the expression of bFGF mRNA, FGF-receptor (FGFR) mRNA and VEGF mRNA was confirmed in all cases including non-neoplastic tissues, adenomas and carcinomas. On <i>in situ</i> hybridization, bFGF mRNA was expressed in carcinoma cells, vascular cells and fibroblastic cells, and the expression ratio of bFGF mRNA in carcinomas was higher than in non-carcinomatous mucosa. VEGF mRNA was expressed in carcinoma cells, medial smooth muscle cells and fibroblastic cells. These results suggest that bFGF and VEGF may contribute to tumor growth in association with neovascularization.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(1), 21-29, 1995-02-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  26

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008603387
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
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