Application of Mucin Histochemistry for Pathological Diagnosis : Expression of Gastric Phenotypes in Metaplastic and Neoplastic Lesions and its Relation to the Organoid Differentiation
-
- OTA Hiroyoshi
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- KATSUYAMA Tsutomu
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- AKAMATSU Taiji
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- FUJIMORI Yoshifumi
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- MATSUZAWA Kenji
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- ISHII Keiko
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- HONDA Takayuki
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- NAKAYAMA Jun
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- FURIHATA Kenichi
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- ONO Kenzo
- Division of Pathology, Tosei General Hospital
-
- MAEDA Koichi
- Department of Pathology, Henry Ford Memorial Hospital
この論文にアクセスする
この論文をさがす
著者
-
- OTA Hiroyoshi
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- KATSUYAMA Tsutomu
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- AKAMATSU Taiji
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- FUJIMORI Yoshifumi
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- MATSUZAWA Kenji
- The second Department of Internal Medicine, Shinshu University School of Meidcine
-
- ISHII Keiko
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- HONDA Takayuki
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- NAKAYAMA Jun
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- FURIHATA Kenichi
- Department of Laboratory Medicine, Shinshu University School of Medicine
-
- ONO Kenzo
- Division of Pathology, Tosei General Hospital
-
- MAEDA Koichi
- Department of Pathology, Henry Ford Memorial Hospital
抄録
Using an array of histochemical and immunohistochemical techniques, we have characterized the various types of mucins in the normal, metaplastic and neoplastic stomach, pancreas and biliary ducts, in the normal and neoplastic esophagus, colon and lung, and in tumors of the ovary. Gastric phenotypes were variously expressed in metaplastic and neoplastic cells in these organs. Their expression was usually associated with an organoid differentiation simulating the gastric pyloric mucosa.<br>In gastric intramucosal carcinoma tissues, neoplastic cells often proliferated forming structures resembling non-neoplastic gastric mucosa. Thus, carcinoma cells in the more superficial layers expressed strong galactose oxidase cold thioneine Schiff reactivity (a surface mucous cell type property), whereas cells in the deeper layers were stained by paradoxical concanavalin A staining (a glandular mucous cell type property). Proliferative cells were perferentially located in the middle layers. This organized differentiation is lost in portions of the tumor that have invaded beyond the muscularis mucosae. Adenocarcinoma cells in both the bile duct and the pancreatic duct, in the bronchioloalveolar carcinoma of the lung and in mucinous cyst adenoma of the ovary showed gastric phenotypes and organoid differentiation. In papillary portions of these tumors, cells in protruded portions of the neoplastic papillae tended to express phenotypes of surface mucous cell, while in the indented portions they expressed phenotypes of glandular mucous cell. The goblet cell metaplasia in areas adjacent to pancreatic ductal carcinoma is identical to gastric pyloric metaplasia.<br>We conclude that the systematic use of mucin histochemistry, a relatively simple technique that can be implemented in most histopathology laboratories, may provide important information about structure and property of neoplastic tissues and could enhance our understanding of carcinogenesis in many organs.
収録刊行物
-
- Acta histochemica et cytochemica
-
Acta histochemica et cytochemica 28(1), 43-53, 1995-02-01
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
参考文献: 79件中 1-79件 を表示
-
1
- The lower esophagus lined by columnar epithelium
-
BARRETT N.
Surgery 41, 881-894, 1957
被引用文献1件
-
2
- Review of 1019 benign ovarian neoplasm
-
BECK R.
Obstet. Gynecol. 16, 482-497, 1960
被引用文献1件
-
3
- Hypertrophy, Hyperplasia, and metaplasia
-
CUBILLA A.
Tumors of the exocrine pancreas., Atlas of Tumor Pathology, 1984
被引用文献1件
-
4
- Ectopic gastric mucosa of the esophagus. A study on histogenesis
-
DE LA PAVA S.
NY State J. Med. 64, 1831-1835, 1964
被引用文献1件
-
5
- Proliferation and differentiation of gastrointestinal cells in health and disease
-
DESCHNER E.
Gastrointestinal cancer 3027, 1978
被引用文献1件
-
6
- <no title>
-
ENTERLINE H.
Pathology of the esophagus., 1984
被引用文献1件
-
7
- Mucin histochemistry of human gallbladder. Changes in adenocarcinoma, cystic fibrosis and cholecystitis
-
ESTERLY J.
J. Natl. Cance Inst. 40, 1-11, 1968
被引用文献1件
-
8
- Muccinous tumor of the ovary. Ultrastructural studies of mucinous cyst adenoma with histogenetic considerations
-
FENOGLIO C.
Cancer 36, 1709-1722, 1975
被引用文献1件
-
9
- Idiopathic inflammatory bowel disease
-
FENOGLIO-PREISER C.
Gastrointestinal pathology An atlas and text., 427-484, 1989
被引用文献1件
-
10
- The histochemistry of intestinal mucins. Changes in disease
-
FILIPE M.
Gastrointestinal and oesophageal pathology, 65-89, 1989
被引用文献1件
-
11
- Characterization of four main cell types in gastric cancer: foveolar, mucopeptic intestinal columnar and goblet cells. An histopathologic, histochemical and ultrastructural study of "early" and "advanced" tumours
-
FIOCCA R.
Path. Res. Pract. 182, 308-325, 1987
被引用文献1件
-
12
- Cell proliferation, differentiation and migration in the gastric mucosa; a study of the background of carcinogenesis
-
FUJITA S.
Pathophysiology of carcinogenesis in digestive organs, 144-160, 1977
被引用文献1件
-
13
- Clinicopathological and immunohistochemical characteristics of goblet cell type adenocarcinoma of the lung
-
GEMMA A.
Acta Pathologica Japonica 41, 737-743, 1991
被引用文献1件
-
14
- Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach
-
GOLDMAN H.
Lab. Invest. 48, 203-210, 1968
被引用文献1件
-
15
- Tritiated thymidine autoradiographic study of cell migration and renewal in the pyloric mucosa of the golden hamster
-
HATTORI T.
Cell Tiss. Res. 175, 49-57, 1976
被引用文献1件
-
16
- Tritiated thymidine autoradiographic study of celllar migration in the gastric gland of the golden hamster
-
HATTORI T.
Cell Tiss. Res. 172, 171-184, 1976
被引用文献1件
-
17
- Barrett's esophagus: Clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics
-
HERLIHY K.
Gastroenterology 86, 436-443, 1984
被引用文献1件
-
18
- Radioautographic study of proliferation in the stomach of the rat using thymidine-3H and compound 48/80
-
HUNT T.
Anat. Rec. 142, 505, 1962
被引用文献1件
-
19
- Adenocarcinoma of the cervical oesophagus arising from ectopic gastric mucosa
-
ISHII K.
Virchows Archiv. A. Pathol. Anat. 419, 159-164, 1991
被引用文献1件
-
20
- The inlet patch: heterotopic gastric mucosa in the upper esophagus
-
JABBARI M.
Gastroenterology 89, 352-256, 1985
被引用文献1件
-
21
- The classification and histogenesis of gastric cancer
-
JARVI O.
Proceedings of XI International Cancer Congress, Florence 1974, 228-234, 1975
被引用文献1件
-
22
- The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma
-
JASS J.
Histochem. J. 13, 191-939, 1981
被引用文献1件
-
23
- Colorectal mucin histochemistry in health and disease: A critical review
-
JASS J.
Pathology International 44, 487-504, 1994
被引用文献1件
-
24
- Histochemical differentiation of complex carbohydrates with variants of the Concanavalian A-horseradish peroxidase method
-
KATSUYAMA T.
J. Histochem. Cytochem. 26, 233-250, 1978
被引用文献1件
-
25
- Recent advances in mucosubstance histochemistry
-
KATSUYAMA T.
Gastric Mucus and Mucus Secretiing Cells, 3-18, 1985
被引用文献1件
-
26
- Human lung cancers expressing gastricc phenotypes
-
KATSUYAMA T.
J. Histochem. Cytochem. 40, 594, 1992
被引用文献1件
-
27
- Mucosubstance histochemistry of the normal mucosa and epithelial neoplasm of the large intestine. GOS reaction and lectin stainings
-
KATSUYAMA T.
Acta Pathol. Jpn. 35, 1409-1425, 1985
被引用文献1件
-
28
- Histochemical characterization of gastric mucin-secreting cells and the surface mucous gel layer
-
KATSUYAMA T.
Gastrointestinal function. Regulation and disturbances 9, 145-165, 1991
被引用文献1件
-
29
- Intracellular microcyst in gastric cancer cells
-
KONDO K.
J. Electronmicroscopy 19, 41-49, 1970
被引用文献1件
-
30
- An ultrastructural study of mucin secreting epithelia in ovarian neoplasm
-
LANGLEY F.
Acta Pathol, Microbiol, Scand. [A] 80(Suppl 233), 76-78, 1972
被引用文献1件
-
31
- The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma an attempt at a histo-clinical classification
-
LAUREN P.
Acta Pathol. et Microbiol. Scandinav. 64, 31-49, 1965
被引用文献1件
-
32
- Cell proliferation kinetics in the gastrointestinal tract of man. II. Cell renewal in stomach, ileum, colon and rectum
-
LIPKIN M.
Gastroenterology 45, 721-729, 1963
被引用文献2件
-
33
- Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas
-
MATSUKURA N.
J. Nat. Cancer Inst. 56, 231-240, 1980
被引用文献1件
-
34
- Zur histogenese und einteilung der ovarialky stome. Ein kritische litratursichtung
-
MAYER R.
Monatsschr. Geburtschilfe Gynaecol. 44, 302-358, 1916
被引用文献1件
-
35
- Intestinal metaplasia and histogenesis of carcinoma in human stomach: Light and electron microscopic study
-
MING S.
Cancer 20, 1418-1429, 1967
被引用文献1件
-
36
- Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances
-
NAKAMURA K.
Gann 59, 251-258, 1968
被引用文献9件
-
37
- Histogenesis of gastric cancer; similarity of cancer cells to the normal epithelial cells of the stomach
-
NAKAMURA K.
J. Clin. Electron Microscopy 8, 5-6, 1975
被引用文献1件
-
38
- Appearance of gastric phenotypes and organoid structure in gastric cancer of differentiated type
-
NAKAMURA Y.
Shinsu Med. J. 39, 731-744, 1991
被引用文献1件
-
39
- Immunohistochemical demonstration of glycoconjugates bearing the type 2 chain-backbone structure in human fetal, normal and neoplastic gastrointestinal tract
-
NAKAYAMA J.
Histochemistry 97, 303-310, 1992
被引用文献1件
-
40
- A new enzyme immunohistochemical technique using alkaline phosphatase-labelled avidin and new fuchsin
-
NANBA K.
Pathology and Clinical Medicine 5, 333-339, 1987
被引用文献1件
-
41
- Ultrastructural immunolocalization of lysozyme in Paneth-like cells undifferentiated (gastric)-type carcinoma of the stomach
-
OHTANI H.
Acta Pathol. Jpn. 38, 861-871, 1988
被引用文献1件
-
42
- Mncosubstance histochemistry of the normal mucosa and epithelial neoplasms of the large intestine
-
ONO K.
Acta Pathol. Jpn. 35, 281-297, 1985
被引用文献1件
-
43
- A dual staining method for identifying mucins of different gastric epithelial mucous cells
-
OTA H.
Histochemical J. 23, 22-28, 1991
被引用文献2件
-
44
- The histologic spectrum of Barrett's esophagus
-
PAULL A.
N. Engi. J. Med. 295, 476-480, 1976
被引用文献1件
-
45
- Aberrant mucosa in the esophagus in infants and in children
-
RECTOR L.
Arch. Pathol. 31, 285-294, 1941
被引用文献1件
-
46
- The distribution of lysozyme in human gastric mucosa in inflammatory and neoplastic disorders
-
REITAMO S.
Acta path. microbiol. scand. Sect. A., 451-456, 1979
被引用文献1件
-
47
- In vitro BrdUrd labeling of solid tumors and immunological determination of labeling index
-
SASAKI K.
J. Histotechnol. 10, 47-49, 1987
被引用文献2件
-
48
- Ultrastructural cell patterns in human gastric carcinoma compared with non-neoplastic gastric mucosa-hitogenetic analysis of carcinoma by mucin histochemistry
-
SASANO N.
J. Nat. Cancer Int. 43, 783-802, 1969
被引用文献1件
-
49
- Light microscopic histochemical detection of sugar residues in secretory glycoproteins of rodent and human tracheal glands with lectin horseradish peroxidase conjugates and the galactose oxidase Schiff sequence
-
SCHULTE B.
J. Histochem. Cytochem. 31, 391-403, 1983
被引用文献1件
-
50
- Light microscopic histochemical detection of terminal galactose oxidase- Schiff sequence and peanut lectin-horseradish peroxidase conjugate
-
SCHULTE B.
J. Histochem. Cytochem. 31, 19-24, 1983
被引用文献1件
-
51
- Effect of tissue fixation on anti-bromodeoxyuridine immunohistochemistry
-
SCHULTE B.
J. Histochem. Cytochem. 35, 1343-1345, 1987
被引用文献1件
-
52
- Histochemical characterization of different types of intestinal metaplasia in gastric mucosa
-
SEGURA D. I.
Cancer 52, 498-503, 1983
被引用文献4件
-
53
- Parietal cell carcinoma
-
SEKI M.
J. Electromicrosocpy 11, 40-46, 1962
被引用文献1件
-
54
- Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells
-
SESSA F.
Gastroenterology 98, 1655-1665, 1990
被引用文献2件
-
55
- Morphogenesis of peripheral type adenocarcinoma of the lung
-
SHIMOSATO Y.
Morphogenesis of the lung cancer 1, 65-89, 1982
被引用文献1件
-
56
- Histochemical Demonstration of Gastrointestinal Mucins in Ovarian Mucinous Cystadenoma
-
SHIOZAWA T.
Acta Path. Jpn. 42, 104-110, 1992
被引用文献1件
-
57
- Histochemistry of mucosubstances in the canine and human respiratory tract
-
SPICER S.
Lab. Invest. 25, 483-490, 1979
被引用文献1件
-
58
- Histochemical properties of the respiratory tract epithelium in different species
-
SPICER S. S.
Am. Rev. Respir. Dis. 128, S20-S26, 1983
被引用文献1件
-
59
- Gastric phenotype expression in human gallbladder cancers revealed by pepsinogen immunohistochemistry and mucin histochemistry
-
TATEMATSU M.
Virchows Archiv. A. 413, 25-32, 1988
被引用文献1件
-
60
- Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry
-
TATEMATSU M.
Acta Pathol Jpn 40, 494-504, 1990
被引用文献12件
-
61
- Markers of surface mucous cell type human gastric cancer cells: Galactose oxidase-Schiff reactive mucins, monoclonal antibody SH-9 reactive mucins and cathepsin E
-
TATEMATSU M.
Acta Pathologica Japonica Original Article 43, 500-506, 1993
被引用文献1件
-
62
- Application of parietal cell autoantibody to histopathological studies
-
TSUTSUMI Y.
Acta Pathol Jpn 35, 823-829, 1985
被引用文献2件
-
63
- Histochemical studies of metaplastic lesions in the human gallbladder
-
TSUTSUMI Y.
Arch.Pathol.Lab.Med. 108, 917-921, 1984
被引用文献5件
-
64
- Ultrastructural and carbohydrate histochemical studies on the differentiation and renewal of mucous cells in the rat gastric fundus
-
WATTEL W.
Cell Tissue Res. 176, 445-462, 1977
被引用文献1件
-
65
- Heterotopic gastric epithelium in the rectum: A report of three new cases with a review of 87 cases of gastric heterotopia in the almentary canal
-
WOLFF M.
J. Clin. Path. 55, 604-616, 1971
被引用文献1件
-
66
- Histochemical demonstration of mucins in the intramucosal laminated structure of human gastric singnet ring cell carcinoma and its relation to submucosal invasion
-
AKAMATSU T
Histochem J 22, 416-425, 1990
DOI 被引用文献5件
-
67
- The role of mucus in the protection of the gastroduodenal mucosa
-
ALLEN A.
Scand. J. Gastroenterol. suppl. 125, 71-77, 1986
DOI 被引用文献5件
-
68
- Gastric parietal cell carcinoma-a newly recognized entity: light microscopic and ultrastructural features
-
CAPELLA C
Histopathology 8, 813-824, 1984
DOI 被引用文献2件
-
69
- Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa; two case reports and review of the literature
-
CHRISTENSEN WN.
Am. J. Surg. Pathol. 11, 397-402, 1987
DOI 被引用文献3件
-
70
- Mucinous tumor of the ovary. III. Histochemical studies
-
FENOGLIO C.
Genecol. Oncol. 4, 151-157, 1976
DOI 被引用文献1件
-
71
- Monoclonal antibody to 5-bromo-and 5-iododeoxyuridine : A new reagent for detection of DNA replication
-
GRATZNER H. G.
Science 218, 474-475, 1982
DOI 被引用文献135件
-
72
- Mucosubstance histochemistry of the normal mucosa and epithelial neoplasms of the lung
-
HONDA T.
Acta Pathol Jpn 36(5), 665-680, 1986
被引用文献4件
-
73
- Histochemical studies of mucosubstances in metaplastic epithelium of the stomach, with special reference to the development of intestinal metaplasia
-
IIDA F
Histochemistry 56, 229-237, 1978
DOI 被引用文献4件
-
74
- Mucin histochemistry of pancreatic duct cell carcinoma, with special reference to organoid differentiation simulating gastric pyloric mucosa
-
MATUZAWA K.
Hum Pathol 23, 925-933, 1992
DOI 被引用文献6件
-
75
- Histochemical demonstration of sugar residues by lectin and immunocytochemical techniques for blood group antigens in human colon
-
NAKAYAM J
Histochemical J. 19, 454-464, 1987
DOI 被引用文献2件
-
76
- Alternating laminated array of two types of mucin in the human gastric surface mucous layer
-
OTA H
Histochem. J. 24, 86-92, 1992
DOI 被引用文献25件
-
77
- Selection of monoclonal antibodies reactive with high molecular weight glycoprotein circulating in body fluid of gastrointestinal cancer patients
-
SAKURAI Y.
Cancer Res. 48, 4053-4058, 1988
被引用文献3件
-
78
- Comparative histochemical study of alimentary tracts with special reference to the mucous neck cells of the stomach
-
SUGANUMA T.
Am. J. Anat. 161, 219-238, 1981
DOI 被引用文献5件
-
79
- Immunohistochemical detection of bromodeoxyuridine in formalin-fixed tissues
-
SUGIHARA H
Histochemistry 85, 193-195, 1986
被引用文献10件
被引用文献: 3件中 1-3件 を表示
-
1
- CLINICO-PATHOLOGICAL FINDINGS OF EPSTEIN-BARR VIRUS-RELATED GASTRIC CANCER
-
TASHIRO Yukie , ARIKAWA Junkou , ITOH Tetsuhiko , TOKUNAGA Masayoshi
Gann monograph on cancer research 45, 87-97, 1998-02
医中誌Web 参考文献23件
-
2
- Phenotypic Immunostaining of Mucus-Secreting Cells of Foregut Origin (Symposium IIIHistochemistry of Glycoconjugates) :
-
Yang Dong-Hua , Tsuyama Shinichiro , Ohmori Jun , Hotta Kyoko , Katsuyama Tsutomu , Murata Fusayoshi
Acta histochemica et cytochemica 32(2), 135-140, 1999
-
3
- 胃粘液様物質を産生する杯細胞型細気管支肺胞上皮癌の1切除例
-
花岡 孝臣 , 関 龍幸
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 14(6), 720-725, 2000-09-15