Temporal Analysis of Increases in c-Fos Expression in Rat Spinal Trigeminal Nucleus Complex by Selective Stimulation of C-afferent Fibers.
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- Tomioka Toshiya
- Second Department of Anesthesiology, Toho University School of Medicine
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This study evaluates temporal increases in the expression of Fos-like immunoreactive labeled neurons (FLI-labeled neurons) in the spinal trigeminal nucleus complex (STNC) following selective stimulation of C-fibers. Selective stimulating C-fibers were obtained using low doses (10 mg/kg b. w.) of capsaicin injection. Under sodium pentobarbital anaesthesia, 1% capsaicin was administered into the rats left infraorbital region. At periods of 30 min, 1, 3, 6, 9 and 12 hr after capsaicin injection, rats were anesthetized and killed for immunohistochemical examination of Fos-like protein products. The results showed that FLI-labeled neurons in the STNC appeared within 30 min after induction of capsaicin injection into the rat trigeminal region, reached peak increases at 3 hr, and disappeared between 9 and 12 hr. This time course was similar to dental treatment results which probably stimulated both A-delta and C fibers. According to previous studies, both A-delta and C fibers are essential to conduct impulses of nociceptive stimulation. But, this theory does not apply to the time course of FLI-labeled neuron expression in the STNC.<BR>In conclusion, this study showed that the time course of FLI-labeled neuron expression in the STNC was unchanged in stimulated or non-stimulated A-delta fibers.
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 28 (3), 269-275, 1995
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詳細情報 詳細情報について
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- CRID
- 1390282679839851776
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- NII論文ID
- 10008603904
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- NII書誌ID
- AA00508022
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- COI
- 1:CAS:528:DyaK28XisFCm
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可