Immunohistochemical Demonstration of Transforming Growth Factor-beta-1 in Human Pituitary Adenomas

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Author(s)

Abstract

The expression of transforming growth factor-beta-1 (TGF-beta-1) was investigated in five normal human pituitary glands and 48 human pituitary adenomas using immunoreactivity to polyclonal antibodies against human TGF-beta-1. The relationship between hormone production and the expression of TGF-beta-1 was also investigated. TGF-beta-1 was detected in both normal cells of pituitary gland and in tumor cells of pituitary adenoma. Fifteen of 48 pituitary adenomas showed positive immunoreactivity for TGF-beta-1. Immunohistochemical staining of serial sections revealed coexpression of TGF-beta-1 and pituitary hormones in pituitary adenomas (PRL, ACTH, GH) and in normal pituitary glands (PRL, ACTH, LH). Intense and widespread positive immunoreactivity was observed in lactotroph cell adenomas. These results suggest TGF-beta-1 may be important in the differentiation and proliferation of the cells of normal adenohypophysis and adenoma.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(4), 333-339, 1995-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  25

Codes

  • NII Article ID (NAID)
    10008604161
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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