The Cytological and Immunohistochemical Study of Septal Cells in the Rat Lung

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Abstract

Septal cells in the alveolar interstitium of the lung have been assumed to be contractile and involved in the regulation of ventilation/perfusion ratio. We studied two cytoskeletal components of the septal cell in the rat lung. One contains thick microfilament bundles: by decoration with heavy meromyosin, the bundle was shown to be composed of actin filaments of opposite polarity. The other contains intermediate filaments: by pre-and post-embedding immunogold electron microscopy, they were shown to contain both desmin and vimentin. Double labeling immunoelectron microscopy further revealed that some intermediate filaments are co-polymers of desmin and vimentin. The features revealed in the present study support the hypothesis that septal cells can contract and change the architecture of the air-blood barrier.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(4), 349-355, 1995-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  30

Codes

  • NII Article ID (NAID)
    10008604223
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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