Atrial Specific Granules : An Intracellular Calcium Store

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Author(s)

    • LING Yiping
    • Department of Biophysics, Shanghai Medical University
    • YU Zhang
    • Department of Biophysics, Shanghai Medical University
    • YU Wenquian
    • Department of Biophysics, Shanghai Medical University
    • OGAWA Kazuo
    • Department of Anatomy, Faculty of Medicine, Kyoto University

Abstract

This work presents evidence that the atrial specific granule (ASG) is one of the intracellular calcium stores (ICaSs). First, a high calcium (Ca) concentration up to 81 mmol/kg dry wt. in ASG was determined by using an electron microscopic x-ray microanalysis technique. Second, Ca<SUP>2+</SUP>-ATPase was observed on the membranes of ASG and of the sarcoplasmic reticulum (SR) by using the cytochemical technique. Third, the activities of the Ca<SUP>2+</SUP>-ATPase on both the ASG membrane and on the SR memebrane were inhibited by 0.1 mM quercetin, but not by 0.1mM oligomycin. Because SR is an established ICaS, the similarities found in the present work between ASG and SR led us to postulate that ASG may be an ICaS in atrial cardiocytes, and that the Ca<SUP>2+</SUP>-ATPase on ASG membrane may pump Ca<SUP>2+</SUP> from cytosol into ASG and thus play a role in maintaining the high Ca concentration in it.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(6), 507-511, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  25

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008604669
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
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