Chinese Traditional Medicine Protects Gastric Parietal Cells from Adriamycin Cytotoxicity

Access this Article

Search this Article

Author(s)

    • YU Xiang Min
    • Department of Anatomy, Faculty of Medicine, Kyoto University
    • LIU You Zhang
    • Department of Anatomy, Faculty of Medicine, Kyoto University
    • NODA Toru
    • Department of Anatomy, Faculty of Medicine, Kyoto University
    • OGAWA Kazuo
    • Department of Anatomy, Faculty of Medicine, Kyoto University

Abstract

The effects of the Chinese traditional drug, Rikkunshito (TJ-43) to adriamycin (ADM) -induced gastric cytotoxicity were studied histo-and cytochemically. Single i. p. injection of ADM (1.0mg/100g b. w.) to rats decreased cytochemical activities of cyto-chrome C oxidase (COX) in mitochondria and Ca<SUP>2+</SUP>-ATPase in plasma membrane of parietal cells. Oral administration of TJ-43 (100 mg/100g b. w.) to rats for 5 days prior to ADM injection almost completely prevented a decrease of both the enzyme activities by ADM. Post-treatment of TJ-43 after ADM injection showed lower intensities of both the enzyme activities than in normal rats, but significantly higher than those of ADM-injected rats without TJ-43 treatment. Localization of lysosomal acid phosphatase (AcPase) appeared to be confined to lysosomes in normal and TJ-43-pre-treated rat parietal cells, but the reaction products in the ADM-treated rat with and without TJ-43 post-treatment tended to disperse into the cytoplasm of most parietal cells. Therefore, a destructive effect of ADM on lysosomal membrane was suggested in ADM-injected rats with and without TJ-43 post-treatment. Taken together, TJ-43 appeared to have preventive effect against ADM-induced cytotoxicity, whereas its post-treatment had partial, but significant curative effects on the parietal cells.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(6), 539-547, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  22

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008604795
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00445991
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top