Immuno-electron Microscopic Demonstration of Luminal Release of Serotonin from Enterochromaffin Cells of Rat Embryo

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The evidence to support the luminal release of serotonin (5HT) from the enterochromaffin cells in rat embryo was demonstrated by immuno-electron microscopic study combined with HPLC measurement of 5HT levels in the lumen. A considerable amount of 5HT was detected in the lumen of embryonic gut. To examine the subcellular localization of 5HT in the EC cells, postembedding immunogold method was used. EC cells in embryonic gut showed a variety of characteristic features as follows. EC cells included secretory granules with high electron-dense cores at basal cytoplasm or both basal and apical cytoplasm. lmmunogold particles were densely packed throughout the cytoplasm rather than concentrating over cores of the secretory granules. In the apical cytoplasm of embryonic EC cells, immunogold particles were densely accumulated at the matrix and over the microvilli. The present findings suggest that 5HT is released into the intestinal lumen in a diacrine manner from embryonic EC cells.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 28(6), 555-563, 1995-12-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008604832
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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