Immunoelectron Microscopic Localization of Copper-Zinc Superoxide Dismutase in Human Gastric Mucosa

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Author(s)

    • NISHIYAMA Jinki
    • First Department of Internal Medicine, Okayama University Medical School
    • MIZUNO Motowo
    • First Department of Internal Medicine, Okayama University Medical School
    • NASU Junichirou
    • First Department of Internal Medicine, Okayama University Medical School
    • KISO Takahiro
    • First Department of Internal Medicine, Okayama University Medical School
    • UESU Tokurou
    • First Department of Internal Medicine, Okayama University Medical School
    • MAGA Toshirou
    • First Department of Internal Medicine, Okayama University Medical School
    • OKADA Hiroyuki
    • First Department of Internal Medicine, Okayama University Medical School
    • TOMODA Jun
    • First Department of Internal Medicine, Okayama University Medical School
    • YAMADA Gotaro
    • First Department of Internal Medicine, Okayama University Medical School
    • TSUJI Takao
    • First Department of Internal Medicine, Okayama University Medical School

Abstract

Superoxide radicals appear to play important roles in the pathogenesis of various gastric mucosal lesions. To add to a greater understanding of the pathogenesis of the various gastric mucosal lesions caused by oxygen-derived free radicals, we examined the distribution of copper-zinc superoxide dismutase (Cu, Zn-SOD) in normal human gastric mucosa using a direct immunoperoxidase method under light and electron microscopy. Under light microscopy, we detected Cu, Zn-SOD in propria gland cells but not in foveolar cells of the fundic mucosa or in antral gland cells. With electron microscopy, Cu, Zn-SOD was detected in the ultrastructural morphology of parietal and chief cells. In parietal cells, it was present mainly in the cytoplasm, partially on the outer membrane of mitochondria, and in the nuclei, and in chief cells, in the cytoplasm. Our findings suggest that Cu, Zn-SOD plays important roles in scavenging oxygen radicals generated in the cytoplasm.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 29(3), 215-220, 1996-06-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  27

Codes

  • NII Article ID (NAID)
    10008605473
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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