Immunocytochimical Evidence for Interleukin-2 Receptor Regulation on Rat Anterior Pituitary and Adrenal Cells

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Abstract

Using a specific monoclonal antibody (mAb) recognizing the rat interleukin-2 receptor (IL-2R) and immunocytochemical techniques, we examined the expression of IL-2R in rat anterior pituitary and adrenal cells <i>in vitro</i>. IL-2R immunoreactivity was seen in a variety types of cells in both the pituitary and adrenals. Under the condition to detect the IL-2R-like immunoreactivity, we found that overnight preincubation with IL-2 enhanced the immunostaining in these cells. Moreover, co-incubation of the cells with dexamethasone attenuated the effect of IL-2 on the IL-2R-like immunostaining. These findings indicate that IL-2R expression in the pituitary and adrenal cells is influenced by IL-2 and glucocorticoid, and support the hypothesis that IL-2 is an immunomediator affecting the pituitary and the adrenal function.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 29(3), 255-260, 1996-06-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  30

Codes

  • NII Article ID (NAID)
    10008605608
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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