Apoptosis with DNA Fragmentation in Bowen's Disease and Szuamous Cell Carcinoma
The clinical phenotypes of Bowen's disease and squamous cell carcinoma (SCC) are very different although the origins of these tumors are epidermal keratinocytes. Here we compared the degree of apoptosis in Bowen's disease and squamous cell carcinoma. In Bowen's disease, several individual tumor cells showed apoptosis. In contrast, apoptosis was not found at the tumor mass where the atypical epidermal cells invaded into the dermis in cases of Bowen's carcinoma and squamous cell carcinoma. The possible molecular mechanisms underlying different behaviors of Bowen's disease and SCC are also discussed.
- Acta histochemica et cytochemica
Acta histochemica et cytochemica 29(3), 261-263, 1996-06-01