Apoptosis with DNA Fragmentation in Bowen's Disease and Squamous Cell Carcinoma.

• Guo Zaipei

  Department of Dermatology, Faculty of Medicine, Kyoto University

• Yoneda Kozo

  Department of Dermatology, Faculty of Medicine, Kyoto University

• Okamoto Hiroyuki

  Department of Dermatology, Faculty of Medicine, Kyoto University

• Imamura Sadao

  Department of Dermatology, Faculty of Medicine, Kyoto University

Abstract

The clinical phenotypes of Bowen's disease and squamous cell carcinoma (SCC) are very different although the origins of these tumors are epidermal keratinocytes. Here we compared the degree of apoptosis in Bowen's disease and squamous cell carcinoma. In Bowen's disease, several individual tumor cells showed apoptosis. In contrast, apoptosis was not found at the tumor mass where the atypical epidermal cells invaded into the dermis in cases of Bowen's carcinoma and squamous cell carcinoma. The possible molecular mechanisms underlying different behaviors of Bowen's disease and SCC are also discussed.

Journal

• ACTA HISTOCHEMICA ET CYTOCHEMICA

  ACTA HISTOCHEMICA ET CYTOCHEMICA 29 (3), 261-263, 1996

  JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Keywords

• Apoptosis
• Epidermis
• Bowen's disease
• Squamous cell carcinoma

Details

• CRID: 1390282679838225664
• NII Article ID: 10008605639
• NII Book ID: AA00508022
• DOI: 10.1267/ahc.29.261
• ISSN: 13475800
• ISSN: 00445991
• Web Site: http://www.jstage.jst.go.jp/article/ahc1968/29/3/29_3_261/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997103360
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed